ArticleProceedings of the National Academy of Sciences of the United States of America2011
Related pituitary cell lineages develop into interdigitated 3D cell networks.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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Who cites it
54 citing papers in PubMed, 109 citations in OpenAlex.
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- BDNF Regulates Pituitary Stem Cell Engagement towards precursor state.bioRxiv : the preprint server for biology · 2026Article
- In vivo effects of cadmium on signaling and secretion of pituitary gonadotrophs in male mice are time-dependent.The Journal of endocrinology · 2025Article
- Fatty Acid Synthase regulates glucose and energy homeostasis via POMC neurons and adrenergic signals.Molecular metabolism · 2025Article
- Prolactin Secretion During Postnatal Development in Artificial Rearing Rats (Rattus norvegicus).Developmental neurobiology · 2025Article
- Gonadotrophs have a dual origin, with most derived from early postnatal pituitary stem cells.Nature communications · 2025Article
- Recent Advances in the Understanding of Gonadotrope Lineage Differentiation in the Developing Pituitary.Neuroendocrinology · 2025Review
- Overview of chromatin regulatory processes during surface ectodermal development and homeostasis.Developmental biology · 2024Review
- Paracrine FGF1 signaling directs pituitary architecture and size.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A transmission electron microscopy investigation suggests that telocytes, skeletal muscles, myoblasts, and stem cells in common carp (Cyprinus carpio) respond to salinity challenges.BMC veterinary research · 2024Article
- Conversion of spikers to bursters in pituitary cell networks: Is it better to disperse for maximum exposure or circle the wagons?PLoS computational biology · 2024Article
- The Neurod1/4-Ntrk3-Src pathway regulates gonadotrope cell adhesion and motility.Cell death discovery · 2023Article
- Revealing Low Amplitude Signals of Neuroendocrine Cells through Disordered Silicon Nanowires-Based Microelectrode Array.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice.Nature communications · 2023Article
- The hidden hedgehog of the pituitary: hedgehog signaling in development, adulthood and disease of the hypothalamic-pituitary axis.Frontiers in endocrinology · 2023Review
- Fast dynamics in the HPA axis: Insight from mathematical and experimental studies.Current opinion in endocrine and metabolic research · 2022Review
- Melanocortin-5 Receptor: Pharmacology and Its Regulation of Energy Metabolism.International journal of molecular sciences · 2022Review
- Corticotroph isolation from Pomc-eGFP mice reveals sustained transcriptional dysregulation characterising a mouse model of glucocorticoid-induced suppression of the hypothalamus-pituitary-adrenal axis.Journal of neuroendocrinology · 2022Article
- Single nucleus transcriptome and chromatin accessibility of postmortem human pituitaries reveal diverse stem cell regulatory mechanisms.Cell reports · 2022Article
- Human anterior pituitary's ACTH cells during the aging process: immunohistochemic and morphometric study.Anatomical science international · 2021Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
The pituitary gland has long been considered to be a random patchwork of hormone-producing cells. By using pituitary-scale tridimensional imaging for two of the least abundant cell lineages, the corticotropes and gonadotropes, we have now uncovered highly organized and interdigitated cell networks that reflect homotypic and heterotypic interactions between cells. Although newly differentiated corticotrope cells appear on the ventral surface of the gland, they rapidly form homotypic strands of cells that extend from the lateral tips of the anterior pituitary along its ventral surface and into the medial gland. As the corticotrope network is established away from the microvasculature, cell morphology changes from rounded, to polygonal, and finally to cells with long cytoplasmic processes or cytonemes that connect corticotropes to the perivascular space. Gonadotropes differentiate later and are positioned in close proximity to corticotropes and capillaries. Blockade of corticotrope terminal differentiation produced by knockout of the gene encoding the transcription factor Tpit results in smaller gonadotropes within an expanded cell network, particularly in the lateral gland. Thus, pituitary-scale tridimensional imaging reveals highly structured cell networks of unique topology for each pituitary lineage. The sequential development of interdigitated cell networks during organogenesis indicate that extensive cell:cell interactions lead to a highly ordered cell positioning rather than random patchwork.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.