ArticleProceedings of the National Academy of Sciences of the United States of America2011
Nonresonant femtosecond laser vaporization of aqueous protein preserves folded structure.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Are Native Conformations of Proteins Retained Throughout Laser Ablation Capture?Analytical chemistry · 2026Article
- Laser-Pulse-Length Effects in Ultrafast Laser Desorption.Analytical chemistry · 2023Article
- Peptide Mass Spectra from Micrometer-Thick Ice Films Produced with Femtosecond Pulses.Analytical chemistry · 2022Article
- Quantification of Protein-Ligand Interactions by Laser Electrospray Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2018Article
- Direct Analysis of Proteins from Solutions with High Salt Concentration Using Laser Electrospray Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2018Article
- Assessment of Reproducibility of Laser Electrospray Mass Spectrometry using Electrospray Deposition of Analyte.Journal of the American Society for Mass Spectrometry · 2017Article
- Isolating Protein Charge State Reduction in Electrospray Droplets Using Femtosecond Laser Vaporization.Journal of the American Society for Mass Spectrometry · 2017Article
- High-Resolution Live-Cell Imaging and Analysis by Laser Desorption/Ionization Droplet Delivery Mass Spectrometry.Analytical chemistry · 2016Article
- Internal energy deposition for low energy, femtosecond laser vaporization and nanospray post-ionization mass spectrometry using thermometer ions.Journal of the American Society for Mass Spectrometry · 2015Article
- Increasing protein charge state when using laser electrospray mass spectrometry.Journal of the American Society for Mass Spectrometry · 2015Article
- Molecular simulation-based structural prediction of protein complexes in mass spectrometry: the human insulin dimer.PLoS computational biology · 2014Article
- Determination of internal energy distributions of laser electrospray mass spectrometry using thermometer ions and other biomolecules.Journal of the American Society for Mass Spectrometry · 2014Article
- Direct electrospray ionization mass spectrometric profiling of real-world samples via a solid sampling probe.Journal of the American Society for Mass Spectrometry · 2013Article
- The effect of a covalent and a noncovalent small-molecule inhibitor on the structure of Abg β-glucosidase in the gas-phase.Journal of the American Society for Mass Spectrometry · 2013Article
- Do charge state signatures guarantee protein conformations?Journal of the American Society for Mass Spectrometry · 2012Article
- Feasibility of depth profiling of animal tissue by ultrashort pulse laser ablation.Analytical chemistry · 2012Article
- Femtosecond laser vaporization that preserves protein-folded structure: an unproven idea.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Femtosecond laser vaporization-based mass spectrometry can be used to measure protein conformation in vitro at atmospheric pressure. Cytochrome c and lysozyme are vaporized from the condensed phase into the gas phase intact when exposed to an intense (10(13) W/cm(2)), nonresonant (800 nm), ultrafast (75 fs) laser pulse. Electrospray postionization time-of-flight mass spectrometry reveals that the vaporized protein maintains the solution-phase conformation through measurement of the charge-state distribution and the collision-induced dissociation channels.
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