Evidence map›Paper›PMID 21746798›Full record

ReviewCold Spring Harbor perspectives in biology2011

Voltage-gated calcium channels.

William A Catterall

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 805 papers.

0numbers the graph read from it
0cells of the map it votes in
805citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

805 citing papers in PubMed, 1,557 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Channels (Austin, Tex.) · 2026
    Article
  5. Voltage-sensing domains: structural and functional diversity.European biophysics journal : EBJ · 2026
    Review
  6. Article
  7. Identification of novel functional sites in the CaProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. CaThe Journal of physiology · 2026
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. IPbioRxiv : the preprint server for biology · 2026
    Article
  15. Review
  16. Impact of CaInternational journal of molecular sciences · 2026
    Review
  17. Review
  18. Article
  19. Review
  20. Article

745 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

William A CatterallDepartment of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA. wcatt@uw.edu
University of Washington · US

Funding

MOLECULAR PROPERTIES OF VOLTAGE-SENSITIVE CHANNELSR01NS022625 · NINDS · UNIVERSITY OF WASHINGTON · PI CATTERALL, WILLIAM A · 1985 to 2019
$6.2M
NINDS NIH HHS R01 NS022625
6 · The paper itself

Abstract

Voltage-gated calcium (Ca(2+)) channels are key transducers of membrane potential changes into intracellular Ca(2+) transients that initiate many physiological events. There are ten members of the voltage-gated Ca(2+) channel family in mammals, and they serve distinct roles in cellular signal transduction. The Ca(V)1 subfamily initiates contraction, secretion, regulation of gene expression, integration of synaptic input in neurons, and synaptic transmission at ribbon synapses in specialized sensory cells. The Ca(V)2 subfamily is primarily responsible for initiation of synaptic transmission at fast synapses. The Ca(V)3 subfamily is important for repetitive firing of action potentials in rhythmically firing cells such as cardiac myocytes and thalamic neurons. This article presents the molecular relationships and physiological functions of these Ca(2+) channel proteins and provides information on their molecular, genetic, physiological, and pharmacological properties.

Indexed as

Calcium SignalingAnimalsCalcium Channel BlockersCalcium ChannelsExcitation Contraction CouplingHumansModels, BiologicalProtein Structure, QuaternaryProtein Structure, TertiarySynaptic TransmissionCalcium Channel BlockersCalcium Channels

Identifiers

PMID21746798
PMCPMC3140680
OpenAlexW2096701787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.