ArticleThe Journal of physiology2011
n-3 polyunsaturated fatty acids in the maternal diet modify the postnatal development of nervous regulation of intestinal permeability in piglets.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Programming Effects of Maternal Nutrition on Intestinal Development and Microorganisms of Offspring: A Review on Pigs.Microorganisms · 2025Review
- Human milkFrontiers in nutrition · 2025Review
- Article
- Development of small intestinal barrier function and underlying mechanism in Chinese indigenous and Duroc piglets during suckling and weaning periods.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Effects of Different Combinations of Sodium Butyrate, Medium-Chain Fatty Acids and Omega-3 Polyunsaturated Fatty Acids on the Reproductive Performance of Sows and Biochemical Parameters, Oxidative Status and Intestinal Health of Their Offspring.Animals : an open access journal from MDPI · 2023Article
- Opioid Use, Gut Dysbiosis, Inflammation, and the Nervous System.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2022Review
- Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Robust, 3-Dimensional Visualization of Human Colon Enteric Nervous System Without Tissue Sectioning.Gastroenterology · 2020Article
- Maternal Soluble Fiber Diet during Pregnancy Changes the Intestinal Microbiota, Improves Growth Performance, and Reduces Intestinal Permeability in Piglets.Applied and environmental microbiology · 2018Article
- Neurons and Glia in the Enteric Nervous System and Epithelial Barrier Function.Physiology (Bethesda, Md.) · 2018Review
- Muscularis macrophage development in the absence of an enteric nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Weaning stress and gastrointestinal barrier development: Implications for lifelong gut health in pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2017Review
- Gene-environment interactions and the enteric nervous system: Neural plasticity and Hirschsprung disease prevention.Developmental biology · 2016Review
- Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications.American journal of physiology. Gastrointestinal and liver physiology · 2015Review
- Building a second brain in the bowel.The Journal of clinical investigation · 2015Review
- Fatty acids, inflammation and intestinal health in pigs.Journal of animal science and biotechnology · 2015Article
- Nutrient-induced changes in the phenotype and function of the enteric nervous system.The Journal of physiology · 2014Review
- The digestive neuronal-glial-epithelial unit: a new actor in gut health and disease.Nature reviews. Gastroenterology & hepatology · 2013Review
- The omega-6 fatty acid derivative 15-deoxy-Δ¹²,¹⁴-prostaglandin J2 is involved in neuroprotection by enteric glial cells against oxidative stress.The Journal of physiology · 2012Article
- Diet and nerves: the impact of maternal feeding on newborn intestinal permeability.The Journal of physiology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestinal epithelial barrier (IEB) plays a key role in the maintenance of gut homeostasis and the development of the immune system in newborns. The enteric nervous system (ENS), a key regulator of gastrointestinal functions, has been shown to be modulated by nutritional factors. However, it remains currently unknown whether maternal diet, in particular n-3 polyunsaturated fatty acids (n-3PUFAs), can impact upon the IEB in newborn piglets and whether the ENS is involved in this effect. Sows received either a control diet (lard based) or an n-3PUFA diet (linseed oil based) during gestation and lactation. Intestinal paracellular permeability was assessed in Ussing chambers on piglets at birth, 3, 7, 14, 21 and 28 postnatal days (PND). Basal jejunal permeability increased significantly and similarly in both groups until PND14 and decreased thereafter. However, at PND28, permeability was higher in n-3PUFA animals as compared to controls. In addition, a vasoactive intestinal peptide (VIP) receptor antagonist increased paracellular permeability in controls but not in n-3PUFA piglets. Conversely, atropine and hexamethonium decreased paracellular permeability in the n-3PUFA group but not in the control group. Moreover, the n-3PUFA diet increased the proportion of choline acetyltransferase (ChAT)-immunoreactive (IR) neurons and decreased the proportion of VIP-IR neurons in the submucosal plexus of piglet jejunum compared to controls. In addition, in primary culture of rat ENS, we showed that 20:5n-3 but not 18:3n-3 increased the proportion of ChAT-IR neurons and decreased the proportion of VIP-IR neurons. In conclusion, supplementation of the maternal diet with n-3PUFAs modified intestinal permeability probably via diet-induced neuroplastic changes in the ENS of newborn piglets.
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