Evidence map›Paper›PMID 21745834›Full record

ArticleSexually transmitted infections2011

Increased gonorrhoea and chlamydia testing did not increase case detection in an HIV clinical cohort 1999-2007.

Stephen A Berry, Khalil G Ghanem, Kathleen R Page, Stephen J Gange, Chloe L Thio, Richard D Moore, Kelly A Gebo

Abstract read
In one paragraph

Article in Sexually transmitted infections, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Chlamydia and Gonorrhea Incidence and Testing Among Patients in the Human Immunodeficiency Virus Outpatient Study (HOPS), 2007-2017.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  3. Article
  4. Article
  5. Article
  6. Budgetary Impact of Compliance With STI Screening Guidelines in Persons Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2017
    Article
  7. Article
  8. Article
  9. Article
  10. Chlamydia trachomatis in human immunodeficiency virus-infected men treated at a referral hospital for sexually transmitted diseases in the Amazonas, Brazil.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephen A BerryDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287-2100, USA. sberry8@jhmi.edu
Khalil G Ghanem
Kathleen R Page
Stephen J Gange
Chloe L Thio
Richard D Moore
Kelly A Gebo

Funding

North American AIDS Cohorts on Collaboration and Design (NAACCORD)U01AI069918 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Keri Nicole Althoff, RICHARD Douglas MOORE · 2006 to 2026
$65.2M
Institute for Clinical and Translational Research (KL2)KL2RR025006 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$12.9M
HIV DISEASE OUTCOMES IN DRUG USERS IN CLINICAL PRACTICER01DA011602 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 1998 to 2013
$10.8M
MID CAREER INVESTIGATOR AWARDK24DA000432 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2000 to 2009
$1.5M
Alcohol and HIV Treatment and Clinical ProgressionR01AA016893 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2008 to 2011
$1.3M
Universal Screening of HIV-Infected Persons for Gonorrhea and ChlamydiaK23AI084854 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BERRY, STEPHEN ARTHUR · 2010 to 2014
$671k
Immunomodulatory Properties of BCG: Implications for MTCTK23HD056957 · NICHD · JOHNS HOPKINS UNIVERSITY · PI PAGE, KATHLEEN R · 2008 to 2012
$667k
CLINICAL OUTCOMES IN ELDERLY HIV PATIENTSR01AG026250 · NIA · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2006 to 2007
$197k
NCRR NIH HHS KL2 RR025006NCRR NIH HHS KL2RR025006-01NIAAA NIH HHS R01 AA016893NIAAA NIH HHS R01 AA16893NIAID NIH HHS K23 AI084854NIAID NIH HHS K23AI084854NIAID NIH HHS U01 AI069918NIA NIH HHS R01 AG026250NICHD NIH HHS K23 HD056957NIDA NIH HHS K24 DA000432NIDA NIH HHS K24 DA00432NIDA NIH HHS R01 DA011602
6 · The paper itself

Abstract

objectivesSince 2003, US organisations have recommended universal screening, rather than targeted screening, of HIV-infected persons for gonorrhoea and chlamydia. The objective of this study was to determine whether wider testing resulting from these guidelines would produce an increase in gonorrhoea/chlamydia diagnoses.

methods3283 patients receiving HIV care in 1999-2007 in the Johns Hopkins Hospital HIV clinic were studied. The two primary outcomes were the occurrence of any gonorrhoea/chlamydia testing in each year of care and the occurrence of any positive result(s) in years of testing. The proportion of all patients in care who were diagnosed with gonorrhoea/chlamydia was defined as the number of patients with positive results divided by the number of patients in care. Trends were analysed with repeated measures logistic regression.

resultsThe proportion of patients tested for gonorrhoea/chlamydia increased steadily from 0.12 in 1999 to 0.33 in 2007 (OR per year for being tested 1.17, 95% CI 1.15 to 1.19). The proportion positive among those tested decreased significantly after 2003 (OR per year 0.67, 95% CI 0.55 to 0.81). The proportion of all patients in care diagnosed with gonorrhoea/chlamydia therefore remained generally stable in 1999-2007 (OR per year 0.97, 95% CI 0.91 to 1.04).

conclusionsUniversal annual screening, as implemented, did not increase the proportion of all patients in care who were diagnosed with gonorrhoea/chlamydia. Similarly low implementation rates have been reported in cross-sectional studies. If future efforts to enhance implementation do not yield increases in diagnoses, then guidelines focusing on targeted screening of high-risk groups rather than universal screening may be warranted.

Indexed as

HIV-1AdolescentAdultAgedAIDS-Related Opportunistic InfectionsAmbulatory CareBacteriological TechniquesBaltimoreChlamydia InfectionsChlamydia trachomatisCohort StudiesFemaleGonorrheaHomosexuality, MaleHumansMale

Identifiers

PMID21745834
PMCPMC3174330

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.