ArticleNeuron2011
Delayed-rectifier K channels contribute to contrast adaptation in mammalian retinal ganglion cells.
Article in Neuron, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Transient and Sustained Ganglion Cell Light Responses Are Differentially Modulated by Intrinsically Produced Reactive Oxygen Species Acting upon Specific Voltage-Gated NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Spike desensitisation as a mechanism for high-contrast selectivity in retinal ganglion cells.Frontiers in cellular neuroscience · 2023Article
- Tandem pore domain acid-sensitive K channel 3 (TASK-3) regulates visual sensitivity in healthy and aging retina.Science advances · 2022Article
- Heterogeneous Temporal Contrast Adaptation in Drosophila Direction-Selective Circuits.Current biology : CB · 2020Article
- The dynamic receptive fields of retinal ganglion cells.Progress in retinal and eye research · 2018Review
- Inferring hidden structure in multilayered neural circuits.PLoS computational biology · 2018Article
- Diversity in spatial scope of contrast adaptation among mouse retinal ganglion cells.Journal of neurophysiology · 2017Article
- A novel mechanism of cone photoreceptor adaptation.PLoS biology · 2017Article
- Article
- Functional Circuitry of the Retina.Annual review of vision science · 2015Article
- Spike-Triggered Covariance Analysis Reveals Phenomenological Diversity of Contrast Adaptation in the Retina.PLoS computational biology · 2015Article
- Ionic mechanisms underlying tonic and phasic firing behaviors in retinal ganglion cells: a model study.Channels (Austin, Tex.) · 2014Article
- Regulation of spatial selectivity by crossover inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Alert response to motion onset in the retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A retinal source of spatial contrast gain control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Time course of dynamic range adaptation in the auditory nerve.Journal of neurophysiology · 2012Article
- Article
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
Retinal ganglion cells adapt by reducing their sensitivity during periods of high contrast. Contrast adaptation in the firing response depends on both presynaptic and intrinsic mechanisms. Here, we investigated intrinsic mechanisms for contrast adaptation in OFF Alpha ganglion cells in the in vitro guinea pig retina. Using either visual stimulation or current injection, we show that brief depolarization evoked spiking and suppressed firing during subsequent depolarization. The suppression could be explained by Na channel inactivation, as shown in salamander cells. However, brief hyperpolarization in the physiological range (5-10 mV) also suppressed firing during subsequent depolarization. This suppression was selectively sensitive to blockers of delayed-rectifier K channels (K(DR)). In somatic membrane patches, we observed tetraethylammonium-sensitive K(DR) currents that activated near -25 mV. Recovery from inactivation occurred at potentials hyperpolarized to V(rest). Brief periods of hyperpolarization apparently remove K(DR) inactivation and thereby increase the channel pool available to suppress excitability during subsequent depolarization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.