ArticleGene expression patterns : GEP2011
A BAC transgenic Hes1-EGFP reporter reveals novel expression domains in mouse embryos.
Article in Gene expression patterns : GEP, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- LINC MIR503HG Controls SC-β Cell Differentiation and Insulin Production by Targeting CDH1 and HES1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation.Cell stem cell · 2021Article
- Article
- Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis.Nature communications · 2017Article
- Genetic visualization of notch signaling in mammalian neurogenesis.Cellular and molecular life sciences : CMLS · 2013Review
- Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism.Development (Cambridge, England) · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Expression of the basic helix-loop-helix factor Hairy and Enhancer of Split-1 (Hes1) is required for normal development of a number of tissues during embryonic development. Depending on context, Hes1 may act as a Notch signalling effector which promotes the undifferentiated and proliferative state of progenitor cells, but increasing evidence also points to Notch independent regulation of Hes1 expression. Here we use high resolution confocal scanning of EGFP in a novel BAC transgenic mouse reporter line, Tg(Hes1-EGFP)(1Hri), to analyse Hes1 expression from embryonic day 7.0 (e7.0). Our data recapitulates some previous observations on Hes1 expression and suggests new, hitherto unrecognised expression domains including expression in the definitive endoderm at early somite stages before gut tube closure and thus preceding organogenesis. This mouse line will be a valuable tool for studies addressing the role of Hes1 in a number of different research areas including organ specification, development and regeneration.
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Registered trials
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