ArticleGenome medicine2011
Systems medicine and integrated care to combat chronic noncommunicable diseases.
Article in Genome medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 71 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on Fluids Associated to Lung Cancer, of the Ectopic Expression of Cancer Testis Gene and Mutation as Diagnostics and Prognosis Biomarkers
Smart Monitoring and Analysis System Based on Artificial Intelligence for Patients With Chronic Heart Failure Using Advanced Mini-Invasive and Wearable Medical Devices
Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014.American journal of respiratory and critical care medicine · 2015Pooled it
- Systematic review and meta-analysis of circulating S100B blood levels in schizophrenia.PloS one · 2014Pooled it
- Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype.PloS one · 2012Trial
- ARIA-EAACI 2025: Person-Centred, Digitally Enabled and Artificial Intelligence-Assisted Change Management in Airway Diseases: An OECD Best Practice for Integrated Care for Chronic Diseases.Clinical and translational allergy · 2026Article
- Bridging policy and practice: a scoping review of health system implementation research practice in Ethiopia.Implementation science communications · 2026Review
- Designing a Digital Twin for the Management of Noncommunicable Diseases: Protocol for a Pilot Study and Methodology Validation.JMIR research protocols · 2026Article
- Understanding Complexities in Collaborative Management of Knowledge on Advance Care Planning for Multi-morbid Patients Within Personalized Integrated Care.Journal of healthcare informatics research · 2025Article
- Exploring the burden of non-communicable diseases on surgical services in Africa: a comprehensive literature review.Annals of medicine and surgery (2012) · 2025Review
- Article
- Prevalence of Overweight and Obesity among Primary School Students in Split, Croatia.Nutrients · 2024Article
- A network medicine approach to study comorbidities in heart failure with preserved ejection fraction.BMC medicine · 2023Article
- Mind body medicine: a modern bio-psycho-social model forty-five years after Engel.BioPsychoSocial medicine · 2023Article
- Developing integrated care pathways for atopic dermatitis-Challenges and unmet needs.Clinical and translational allergy · 2023Article
- Systems Medicine Approach for Tinnitus with Comorbid Disorders.Nutrients · 2022Article
- Open Innovation as the Catalyst in the Personalized Medicine to Personalized Digital Medicine Transition.Journal of personalized medicine · 2022Article
- Mitochondrial Dysfunction in Alzheimer's Disease: Opportunities for Drug Development.Current neuropharmacology · 2022Article
- Impact of the COVID-19 Pandemic on Patients Affected by Non-Communicable Diseases in Europe and in the USA.International journal of environmental research and public health · 2021Article
- Barriers and facilitators in the implementation of bio-psychosocial care at the primary healthcare level in South Kivu, Democratic Republic of Congo.African journal of primary health care & family medicine · 2021Article
- A Systematic Review of Asthma Phenotypes Derived by Data-Driven Methods.Diagnostics (Basel, Switzerland) · 2021Review
- Inflammation/bioenergetics-associated neurodegenerative pathologies and concomitant diseases: a role of mitochondria targeted catalase and xanthophylls.Neural regeneration research · 2021Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
64 authors.
Funding
Abstract
We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.