ArticleBMC infectious diseases2011
Antiretroviral treatment reverses HIV-associated anemia in rural Tanzania.
Article in BMC infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Trial
- Effect of vitamin A and vitamin C supplementation on oxidative stress in HIV and HIV-TB co-infection at Lagos University Teaching Hospital (LUTH) Nigeria.African health sciences · 2017Trial
- Antiretroviral Treatment Is Associated With Iron Deficiency in HIV-Infected Malawian Women That Is Mitigated With Supplementation, but Is Not Associated With Infant Iron Deficiency During 24 Weeks of Exclusive Breastfeeding.Journal of acquired immune deficiency syndromes (1999) · 2015Trial
- Trial
- Prevalence and correlates of cytopenias in HIV-infected adults initiating highly active antiretroviral therapy in Uganda.BMC infectious diseases · 2014Trial
- Cytopenias in context: ethnoracial hematological trends among HIV-infected Africans and Russians: a review.Annals of medicine and surgery (2012) · 2026Review
- Causes and Consequences of Persistent Anemia after 6 Months of Antiretroviral Therapy in Tanzania: An Observational Comparative Cohort Study.The American journal of tropical medicine and hygiene · 2025Observational
- Cytopenias and Associated Factors in Patients Living With HIV on ARV Treatment in Cameroon: An Analytical Cross-Sectional Study.Advances in hematology · 2025Article
- Article
- Review
- The burden of anemia among Chinese HIV-infected patients following the initiation of antiretroviral therapy in the treat-all era: a nationwide cohort study.BMC infectious diseases · 2023Article
- Severity and Determinants of Anemia in TB/HIV Coinfected Adults at Mekelle, Ethiopia: Hospital Based Retrospective Study.Journal of tropical medicine · 2023Article
- Article
- Article
- Achievements and Challenges in the Prevention of Mother-to-Child Transmission of HIV-A Retrospective Cohort Study from a Rural Hospital in Northern Tanzania.International journal of environmental research and public health · 2021Article
- Prevalence and Risk Factors of Cytopenia in HIV-Infected Patients before and after the Initiation of HAART.BioMed research international · 2020Article
- Prevalence and Predictors of Anemia in HIV-Infected Persons in Nepal.HIV/AIDS (Auckland, N.Z.) · 2020Article
- Prevalence and associated factors of anemia among adult human immune deficiency virus positive patients on anti-retroviral therapy at Debre tabor Hospital, Northwest Ethiopia.BMC research notes · 2019Article
- Imbalance of antioxidant enzymes activities and trace elements levels in Ghanaian HIV-infected patients.PloS one · 2019Article
- Prevalence and predictors of anemia among adult HIV infected patients at the University of Gondar Hospital, Northwest Ethiopia.HIV/AIDS (Auckland, N.Z.) · 2019Article
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Abstract
backgroundHIV-associated anemia is common and associated with poor prognosis. However, its response to antiretroviral treatment (ART) in rural Africa is poorly understood.
methodsHIV-infected adults (≥15 years) who enrolled in HIV care at Haydom Lutheran Hospital in northern Tanzania were included in the study. The effect of ART (zidovudine/stavudine + lamivudine + efavirenz/nevirapine) on HIV-associated anemia was studied in a subset of patients who were anemic at the time they started ART and had a follow-up hemoglobin measurement 12 months later. Pregnant women were excluded from the study, as were women who had given birth within the past 6 weeks. Anemia was defined as hemoglobin <12 g/dL in women and <13 g/dL in men. We applied paired sample T-tests to compare hemoglobin levels before and one year after ART initiation, and logistic regression models to identify predictors of persistent anemia.
resultsAt enrollment, mean hemoglobin was 10.3 g/dL, and 649 of 838 patients (77.4%) were anemic. Of the anemic patients, 254 (39.1%) had microcytosis and hypochromia. Among 102 patients who were anemic at ART initiation and had a follow-up hemoglobin measurement after 12 months, the mean hemoglobin increased by 2.5 g/dL (P < 0.001); however, 39 patients (38.2%) were still anemic after 12 months of ART. Independent predictors of persistent anemia were mean cell volume in the lower quartile (<76.0 fL; Odds Ratio [OR] 4.34; 95% confidence interval [CI] 1.22-15.5) and a zidovudine-containing initial regimen (OR 2.91; 95% CI 1.03-8.19).
conclusionsMost patients had anemia at enrollment, of whom nearly 40% had microcytosis and hypochromia suggestive of iron deficiency. The mean hemoglobin increased significantly in patients who received ART, but one third were still anemic 12 months after ART initiation indicating that additional interventions to treat HIV-associated anemia in rural Africa might be warranted, particularly in patients with microcytosis and those treated with zidovudine.
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