ArticleBMC evolutionary biology2011
Genetic adaptation of the antibacterial human innate immunity network.
Article in BMC evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Spatial Modularity of Innate Immune Networks Across Bactrian Camel Tissues.Animals : an open access journal from MDPI · 2025Article
- The Effect of Developmental Pleiotropy on the Evolution of Insect Immune Genes.Genome biology and evolution · 2023Article
- Divergence in Coding Sequence and Expression of Different Functional Categories of Immune Genes between Two Wild Rodent Species.Genome biology and evolution · 2021Article
- Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses.Nature immunology · 2018Article
- β-defensins: An innate defense for bovine mastitis.Veterinary world · 2017Review
- Article
- Natural Selection in the Great Apes.Molecular biology and evolution · 2016Article
- Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes.American journal of human genetics · 2016Article
- Interleukin-37 gene variants segregated anciently coexist during hominid evolution.European journal of human genetics : EJHG · 2015Article
- Population and genomic lessons from genetic analysis of two Indian populations.Human genetics · 2014Article
- Population genetic tools for dissecting innate immunity in humans.Nature reviews. Immunology · 2013Review
- Adaptive evolution: evaluating empirical support for theoretical predictions.Nature reviews. Genetics · 2012Review
- Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly.Immunity · 2012Review
- Article
- Genetic variation in Toll-like receptors and disease susceptibility.Nature immunology · 2012Review
- Is Immune Aging a Cause of Disease among the Elderly, or is it a Passive Indicator of General Decline of Physiologic Function?Aging and disease · 2011Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundPathogens have represented an important selective force during the adaptation of modern human populations to changing social and other environmental conditions. The evolution of the immune system has therefore been influenced by these pressures. Genomic scans have revealed that immune system is one of the functions enriched with genes under adaptive selection.
resultsHere, we describe how the innate immune system has responded to these challenges, through the analysis of resequencing data for 132 innate immunity genes in two human populations. Results are interpreted in the context of the functional and interaction networks defined by these genes. Nucleotide diversity is lower in the adaptors and modulators functional classes, and is negatively correlated with the centrality of the proteins within the interaction network. We also produced a list of candidate genes under positive or balancing selection in each population detected by neutrality tests and showed that some functional classes are preferential targets for selection.
conclusionsWe found evidence that the role of each gene in the network conditions the capacity to evolve or their evolvability: genes at the core of the network are more constrained, while adaptation mostly occurred at particular positions at the network edges. Interestingly, the functional classes containing most of the genes with signatures of balancing selection are involved in autoinflammatory and autoimmune diseases, suggesting a counterbalance between the beneficial and deleterious effects of the immune response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.