ArticleBMC evolutionary biology2011
The genome sequence of Brucella pinnipedialis B2/94 sheds light on the evolutionary history of the genus Brucella.
Article in BMC evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 43 citations in OpenAlex.
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- Multi-locus variable-number tandem repeat analysis of Chinese Brucella strains isolated from 1953 to 2013.Infectious diseases of poverty · 2017Article
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- Biochemical and spectroscopic properties of Brucella microti glutamate decarboxylase, a key component of the glutamate-dependent acid resistance system.FEBS open bio · 2015Article
- Glutamate decarboxylase-dependent acid resistance in Brucella spp.: distribution and contribution to fitness under extremely acidic conditions.Applied and environmental microbiology · 2015Article
- Development and assessment of multiplex high resolution melting assay as a tool for rapid single-tube identification of five Brucella species.BMC research notes · 2014Article
- Brucella papionis sp. nov., isolated from baboons (Papio spp.).International journal of systematic and evolutionary microbiology · 2014Article
- Comparative phylogenomics and evolution of the Brucellae reveal a path to virulence.Journal of bacteriology · 2014Article
- Retrospective and prospective perspectives on zoonotic brucellosis.Frontiers in microbiology · 2014Review
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- Developing insights into the mechanisms of evolution of bacterial pathogens from whole-genome sequences.Future microbiology · 2012Review
- Genotyping of Brucella species using clade specific SNPs.BMC microbiology · 2012Article
- Brucella ceti and brucellosis in cetaceans.Frontiers in cellular and infection microbiology · 2012Review
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5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince the discovery of the Malta fever agent, Brucella melitensis, in the 19th century, six terrestrial mammal-associated Brucella species were recognized over the next century. More recently the number of novel Brucella species has increased and among them, isolation of species B. pinnipedialis and B. ceti from marine mammals raised many questions about their origin as well as on the evolutionary history of the whole genus.
resultsWe report here on the first complete genome sequence of a Brucella strain isolated from marine mammals, Brucella pinnipedialis strain B2/94. A whole gene-based phylogenetic analysis shows that five main groups of host-associated Brucella species rapidly diverged from a likely free-living ancestor close to the recently isolated B. microti. However, this tree lacks the resolution required to resolve the order of divergence of those groups. Comparative analyses focusing on a) genome segments unshared between B. microti and B. pinnipedialis, b) gene deletion/fusion events and c) positions and numbers of Brucella specific IS711 elements in the available Brucella genomes provided enough information to propose a branching order for those five groups.
conclusionsIn this study, it appears that the closest relatives of marine mammal Brucella sp. are B. ovis and Brucella sp. NVSL 07-0026 isolated from a baboon, followed by B. melitensis and B. abortus strains, and finally the group consisting of B. suis strains, including B. canis and the group consisting of the single B. neotomae species. We were not able, however, to resolve the order of divergence of the two latter groups.
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