ArticleGenes, brain, and behavior2011
5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination.
Article in Genes, brain, and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 76 citations in OpenAlex.
- 5-HTTLPR does not moderate the effect of attention bias modification for depression: a randomized sham-controlled trial.Translational psychiatry · 2025Trial
- Spiritual walking and stress resilience integrating psychological endocrine and genetic evidence from a longitudinal Iraqi cohort.Discover mental health · 2026Article
- Molecules of mood: the integrated molecular transducers of exercise's antidepressant effects.Molecular genetics and genomics : MGG · 2026Review
- The Role of BDNF in Experimental and Clinical Traumatic Brain Injury.International journal of molecular sciences · 2021Review
- Interaction Between the 5-Hydroxytryptamine Transporter-Linked Polymorphic Region (5-HTTLPR) and Negative Life Events in Adolescent Heavy Drinking.Journal of studies on alcohol and drugs · 2020Article
- Adults with Autism and Adults with Depression Show Similar Attentional Biases to Social-Affective Images.Journal of autism and developmental disorders · 2020Article
- Genome-wide association analysis reveals KCTD12 and miR-383-binding genes in the background of rumination.Translational psychiatry · 2019Article
- The Influence of the Val66Met Polymorphism of Brain-Derived Neurotrophic Factor on Neurological Function after Traumatic Brain Injury.Journal of Alzheimer's disease : JAD · 2018Review
- The interaction between 5-HTTLPR and stress exposure influences connectivity of the executive control and default mode brain networks.Brain imaging and behavior · 2017Observational
- Partial replication of two rumination-related candidate gene studies.Cognition & emotion · 2017Article
- Predicting attention-deficit/hyperactivity disorder severity from psychosocial stress and stress-response genes: a random forest regression approach.Translational psychiatry · 2017Article
- Brain-Derived Neurotrophic Factor Val66Met Polymorphism Affects the Relationship Between an Anxiety-Related Personality Trait and Resting Regional Cerebral Blood Flow.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Traumatic Life Events in Relation to Cognitive Flexibility: Moderating Role of the BDNF Val66Met Gene Polymorphism.Frontiers in behavioral neuroscience · 2017Article
- Differential sensitivity to the environment: contribution of cognitive biases and genes to psychological wellbeing.Molecular psychiatry · 2016Article
- BDNF Val66Met genotype determines hippocampus-dependent behavior via sensitivity to glucocorticoid signaling.Molecular psychiatry · 2016Article
- Distinct effects of folate pathway genes MTHFR and MTHFD1L on ruminative response style: a potential risk mechanism for depression.Translational psychiatry · 2016Article
- Inhibition of Attention for Affective Material: Contributions byPsychology & neuroscience · 2015Article
- Integrating NIMH Research Domain Criteria (RDoC) into Depression Research.Current opinion in psychology · 2015Article
- Dysfunctional Attitudes and Affective Responses to Daily Stressors: Separating Cognitive, Genetic, and Clinical Influences on Stress Reactivity.Cognitive therapy and research · 2015Article
- Predicting change in symptoms of depression during the transition to university: the roles of BDNF and working memory capacity.Cognitive, affective & behavioral neuroscience · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
This study examined whether polymorphisms in the serotonin transporter (SLC6A4, 5-HTTLPR) and brain-derived neurotropic factor (BDNF Val66Met, rs6265) genes moderate the relationship between life stress and rumination. Participants were a large homogenous group of healthy, unmedicated, never depressed individuals with few current symptoms of depression (N = 273). Results indicate that individuals with two short (S) alleles of the 5-HTTLPR polymorphism or two Met alleles of the BDNF Val66Met polymorphism ruminate more under conditions of life stress, compared to the other genotypes. Moreover, the accumulation of risk alleles (i.e. S and Met alleles) across genes is associated with significantly greater rumination in the context of life stress. These results suggest that both 5-HTTLPR and BDNF Val66Met moderate the relationship between life stress and rumination. These findings support the notion that variation in these genes is associated with biological sensitivity to the negative effects of stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.