ArticleLiver international : official journal of the International Association for the Study of the Liver2012
All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
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Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Application of artificial intelligence in chronic liver diseases: a systematic review and meta-analysis.BMC gastroenterology · 2021Pooled it
- KASL clinical practice guidelines: management of alcoholic liver disease.Clinical and molecular hepatology · 2013Guideline
- Recurrent and De Novo Cirrhosis After Liver Transplantation.Portal hypertension & cirrhosis · 2026Article
- Article
- Detecting decompensation in cirrhotic patients with varying ascitic volumes using magnetic resonance elastography.Abdominal radiology (New York) · 2026Article
- Prognostic value of easy Albumin-Bilirubin score in liver cirrhosis: a comparison with established scoring systems.European journal of gastroenterology & hepatology · 2026Article
- Association of Cirrhosis Etiology With Outcomes after Transjugular Intrahepatic Portosystemic Shunt: A National Cohort Study.Gastro hep advances · 2026Article
- Aspirin reduces short-term mortality risk in critically ill patients with liver cirrhosis: a propensity-score matched retrospective analysis using the MIMIC-IV database.BMC gastroenterology · 2025Article
- Clinical Impact of Continuation Versus Cessation of Antiviral Therapy in Chronic Hepatitis B: A Modelling Study With Implications for Hepatitis B Cure.Journal of viral hepatitis · 2025Article
- Screening of advanced fibrosis and metabolic dysfunction-associated steatotic liver disease using transient elastography in vulnerable population.Scientific reports · 2025Article
- Mortality in Autoimmune Liver Disease in Sweden: A Population-Based Cohort Study of 9,654 Patients.Liver international : official journal of the International Association for the Study of the Liver · 2025Article
- Role of Uncertainty in Illness and Coping Strategies in Advance Directive Completion in Patients With End-stage Liver Disease.Journal of clinical gastroenterology · 2025Article
- Liver cirrhosis in 2021: Global Burden of Disease study.PloS one · 2025Article
- Risk factors for hepatocellular carcinoma in cirrhosis: A comprehensive analysis from a decade-long study.World journal of gastrointestinal oncology · 2024Review
- Diffuse and focal liver fat: advanced imaging techniques and diagnostic insights.Abdominal radiology (New York) · 2024Review
- Qualitative service evaluation of a multimodal pilot service for early detection of liver disease in high-risk groups: 'Alright My Liver?'BMJ open gastroenterology · 2024Article
- Transcriptome Analyses of Liver Sinusoidal Endothelial Cells Reveal a Consistent List of Candidate Genes Associated with Endothelial Dysfunction and the Fibrosis Progression.Current issues in molecular biology · 2024Article
- [Pay attention to the diagnosis and treatment of "easily neglected" complications in liver cirrhosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024Article
- Article
- Role of oral Midodrine in preventing hepatorenal syndrome in Child-Turcotte-Pugh class C cirrhotics: a pilot study.Gastroenterology and hepatology from bed to bench · 2024Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
backgroundMortality due to cirrhosis has tripled over the last 30 years in the UK. However, we lack adequate, contemporary, population-based estimates of the excess mortality patients who are at risk compared with the general population.
aimTo determine the overall survival in patients with cirrhosis compared with the general population taking into account the effects of severity and aetiology of disease and comorbidity.
methodsIn a cohort study, we identified 4537 people with cirrhosis and a control cohort of 44 403 patients, matched by age, sex and general practice from the UK General Practice Research Database between June 1987 and April 2002.
resultsPatients with compensated cirrhosis had a nearly five-fold [hazard ratio (HR) 4.7, 95% confidence interval (CI) 4.4-5.0] increased risk of death, while those with decompensated cirrhosis had a near 10-fold (HR 9.7, 95% CI 8.9-10.6) increased risk compared with the general population. Alcoholic cirrhosis conferred a worse prognosis than non-alcohol-related cirrhosis both in the first year following diagnosis and subsequently.
conclusionHaving a diagnosis of cirrhosis confers a substantial increased mortality risk compared with the general population, even for those with compensated disease, with 5-year survival between that seen for breast and colorectal cancer.
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