ArticleAmyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases2011
Progression of white matter degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging study.
Article in Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The value of magnetic resonance imaging as a biomarker for amyotrophic lateral sclerosis: a systematic review.BMC neurology · 2016Pooled it
- Mapping motor and extra-motor gray and white matter changes in ALS: a comprehensive review of MRI insights.Neuroradiology · 2025Review
- Evaluating machine learning pipelines for multimodal neuroimaging in small cohorts: an ALS case study.Frontiers in neuroinformatics · 2025Article
- Toward diffusion tensor imaging as a biomarker in neurodegenerative diseases: technical considerations to optimize recordings and data processing.Frontiers in human neuroscience · 2024Review
- Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis.BMJ (Clinical research ed.) · 2023Review
- Sequential alterations in diffusion metrics as correlates of disease severity in amyotrophic lateral sclerosis.Journal of neurology · 2023Article
- Diffusion Tensor Imaging in Amyotrophic Lateral Sclerosis: Machine Learning for Biomarker Development.International journal of molecular sciences · 2023Review
- Distinct patterns of progressive gray and white matter degeneration in amyotrophic lateral sclerosis.Human brain mapping · 2022Article
- Simultaneous PET/MRI: The future gold standard for characterizing motor neuron disease-A clinico-radiological and neuroscientific perspective.Frontiers in neurology · 2022Review
- Neuroanatomical associations of the Edinburgh cognitive and Behavioural ALS screen (ECAS).Brain imaging and behavior · 2021Article
- A prospective harmonized multicenter DTI study of cerebral white matter degeneration in ALS.Neurology · 2020Article
- Precentral degeneration and cerebellar compensation in amyotrophic lateral sclerosis: A multimodal MRI analysis.Human brain mapping · 2019Article
- Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS.Journal of neurology, neurosurgery, and psychiatry · 2019Article
- Tract integrity in amyotrophic lateral sclerosis: 6-month evaluation using MR diffusion tensor imaging.BMC medical imaging · 2019Article
- Tracking a Fast-Moving Disease: Longitudinal Markers, Monitoring, and Clinical Trial Endpoints in ALS.Frontiers in neurology · 2019Review
- Positron Emission Tomography Molecular Imaging Biomarkers for Amyotrophic Lateral Sclerosis.Frontiers in neurology · 2019Review
- Imaging the pathoanatomy of amyotrophic lateral sclerosis in vivo: targeting a propagation-based biological marker.Journal of neurology, neurosurgery, and psychiatry · 2018Article
- Article
- The two-year progression of structural and functional cerebral MRI in amyotrophic lateral sclerosis.NeuroImage. Clinical · 2018Article
- Imaging Biomarkers for the Diagnosis and Prognosis of Neurodegenerative Diseases. The Example of Amyotrophic Lateral Sclerosis.Frontiers in neuroscience · 2018Review
Corrections and comments
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8 authors.
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Abstract
Whether longitudinal diffusion tensor MRI imaging (DTI) can capture disease progression in patients with amyotrophic lateral sclerosis (ALS) is unclear. The primary goal of this study was to determine if DTI detects progression of the corticospinal tracts (CST) degeneration in ALS. Seventeen ALS patients and 19 age- and gender-matched healthy controls were scanned with DTI at baseline for cross-sectional analyses. For longitudinal analyses, the ALS patients had repeat DTI scans after eight months. Tractography of the CST was used to guide regions-of-interest (ROI) analysis and complemented by a voxelwise analysis. Cross-sectional study found that baseline FA of the right superior CST was markedly reduced in ALS patients compared to controls. The FA reductions in this region correlated with the disease severity in ALS patients. Longitudinal study found that FA change rate of the right superior CST significantly declined over time. In conclusion, longitudinal DTI study captures progression of upper motor fiber degeneration in ALS. DTI can be useful for monitoring ALS progression and efficacy of treatment interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.