ArticleJournal of the American Chemical Society2011
Synthetic versatility in C-H oxidation: a rapid approach to differentiated diols and pyrans from simple olefins.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- General Regio- and Diastereoselective Allylic C-H Oxygenation of Internal Alkenes.Journal of the American Chemical Society · 2024Article
- One-pot chlorocarboxylation of toluenes with chlorine dioxide under photoirradiation.RSC advances · 2022Article
- Metal-Free C-H Functionalization of Allenamides: An Access to Branched Allylic Esters.ACS omega · 2019Article
- Operando Spectroscopic and Kinetic Characterization of Aerobic Allylic C-H Acetoxylation Catalyzed by Pd(OAc)Journal of the American Chemical Society · 2019Article
- Oxidation of Hindered Allylic C-H Bonds with Applications to the Functionalization of Complex Molecules.ACS catalysis · 2017Article
- The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer.Molecules (Basel, Switzerland) · 2017Review
- The design of a readily attachable and cleavable molecular scaffold forChemical science · 2016Article
- N-Boc amines to oxazolidinones via Pd(II)/bis-sulfoxide/Brønsted acid co-catalyzed allylic C-H oxidation.Journal of the American Chemical Society · 2014Article
- Terminal olefins to chromans, isochromans, and pyrans via allylic C-H oxidation.Journal of the American Chemical Society · 2014Article
- Catalyst-controlled C-O versus C-N allylic functionalization of terminal olefins.Journal of the American Chemical Society · 2013Article
- Terminal olefins to linear α,β-unsaturated ketones: Pd(II)/hypervalent iodine co-catalyzed Wacker oxidation-dehydrogenation.Journal of the American Chemical Society · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Conventionally, C-H oxidation reactions are used to install functional groups. The use of C-H oxidation to transform simple starting materials into highly versatile intermediates, which enable rapid access to a range of complex target structures, is a new area with tremendous potential in synthesis. Herein we report a Pd(II)/sulfoxide-catalyzed allylic C-H oxidation to form anti-1,4-dioxan-2-ones from homoallylic oxygenates. These versatile building blocks are rapidly elaborated to differentiated syn-1,2-diols, stereodefined amino-polyols, and syn-pyrans, structures ubiquitous in medicinally important complex molecules found in Nature. We also demonstrate that a C-H oxidation approach to the synthesis of these motifs is orthogonal and complementary to other state-of-the-art methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.