ArticleJournal of the American Chemical Society2011
Highly enantioselective direct alkylation of arylacetic acids with chiral lithium amides as traceless auxiliaries.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Hydrophobic pocket engineering of arylmalonate decarboxylase expands its substrate scope towards the synthesis of the (Chemical communications (Cambridge, England) · 2026Article
- Copper(I)-Catalyzed Enantioselective α-Alkylation of 2-Acylimidazoles.Journal of the American Chemical Society · 2024Article
- A biocatalytic platform for asymmetric alkylation of α-keto acids by mining and engineering of methyltransferases.Nature communications · 2023Article
- Copper(I)-catalyzed asymmetric alkylation of α-imino-esters.Nature communications · 2023Article
- Diastereo- and Enantioselective Reductive Mannich-type Reaction of α,β-Unsaturated Carboxylic Acids to Ketimines: A Direct Entry to Unprotected βChemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Lithium Enolate with a Lithium-Alkyne Interaction in the Enantioselective Construction of Quaternary Carbon Centers: Concise Synthesis of (+)-Goniomitine.Angewandte Chemie (International ed. in English) · 2022Article
- Stereoselective Alkylation of Chiral Titanium(IV) Enolates withOrganic letters · 2021Article
- Recent Advances in the Synthesis of Ibuprofen and Naproxen.Molecules (Basel, Switzerland) · 2021Review
- Computational design of syntheses leading to compound libraries or isotopically labelled targets.Chemical science · 2019Article
- Enantioselective Alkylation of 2-Alkylpyridines Controlled by Organolithium Aggregation.Journal of the American Chemical Society · 2019Article
- Total Synthesis of Unsymmetrically Oxidized Nuphar Thioalkaloids via Copper-Catalyzed Thiolane Assembly.Journal of the American Chemical Society · 2017Article
- Catalytic Desymmetrization by C-H Functionalization as a Solution to the Chiral Methyl Problem.Angewandte Chemie (International ed. in English) · 2017Article
- Determination of the Absolute Configuration of β-Chiral Primary Alcohols Using the Competing Enantioselective Conversion Method.Organic letters · 2017Article
- Lithium Enolates in the Enantioselective Construction of Tetrasubstituted Carbon Centers with Chiral Lithium Amides as Noncovalent Stereodirecting Auxiliaries.Journal of the American Chemical Society · 2017Article
- Asymmetric Synthesis of γ-Lactones through Koga Amine-Controlled Addition of Enediolates to α,β-Unsaturated Sulfoxonium Salts.The Journal of organic chemistry · 2017Article
- Article
- Mixed Aggregates of the Dilithiated Koga Tetraamine: NMR Spectroscopic and Computational Studies.Angewandte Chemie (International ed. in English) · 2016Article
- 10-Step Asymmetric Total Synthesis and Stereochemical Elucidation of (+)-Dragmacidin D.Angewandte Chemie (International ed. in English) · 2015Article
- Direct enantioselective conjugate addition of carboxylic acids with chiral lithium amides as traceless auxiliaries.Journal of the American Chemical Society · 2015Article
- Diastereo- and enantioselective iridium-catalyzed allylation of cyclic ketone enolates: synergetic effect of ligands and barium enolates.Journal of the American Chemical Society · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A direct, highly enantioselective alkylation of arylacetic acids via enediolates using a readily available chiral lithium amide as a stereodirecting reagent has been developed. This approach circumvents the traditional attachment and removal of chiral auxiliaries used currently for this type of transformation. The protocol is operationally simple, and the chiral reagent is readily recoverable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.