ArticleInternational journal of geriatric psychiatry2012
Longitudinal stability of subsyndromal symptoms of depression in individuals with mild cognitive impairment: relationship to conversion to dementia after 3 years.
Article in International journal of geriatric psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Longitudinal course of behavioural and psychological symptoms of dementia: systematic review.The British journal of psychiatry : the journal of mental science · 2016Pooled it
- The mediating role of daily living ability and sleep in depression and cognitive function based on a structural equation model.BMC geriatrics · 2025Article
- Amyloid pathology modulates the relationship between subsyndromal symptomatic depression and tau accumulation in non-demented older adults.Frontiers in aging neuroscience · 2025Article
- Baseline CSF ferritin levels were associated with trajectories of depressive symptoms among older people without dementia.Frontiers in aging neuroscience · 2025Article
- Implications of helplessness in depression: diagnosing mild cognitive impairment and analyzing its effects on cognitive decline in older adults.Frontiers in aging neuroscience · 2024Article
- Examining heterogeneity in depression symptoms and associations with cognition and everyday function in MCI.Journal of clinical and experimental neuropsychology · 2022Article
- Neuropsychiatric symptoms in at-risk groups for AD dementia and their association with worry and AD biomarkers-results from the DELCODE study.Alzheimer's research & therapy · 2020Article
- Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives.Frontiers in aging neuroscience · 2020Review
- Personalized Risk Index for Neurocognitive Decline Among People With Well-Controlled HIV Infection.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Article
- Sex Differences in the Relationship between Depressive Symptoms and Risk of Amnestic Mild Cognitive Impairment.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Article
- Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2016Observational
- Comparing Patient-Reported Outcomes Measure Information System Depression Scale with Legacy Depression Measures in a Community Sample of Older Adults with Varying Levels of Cognitive Functioning.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2015Article
- Alzheimer's Disease Neuroimaging Initiative 2 Clinical Core: Progress and plans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Review
- 2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Review
- Sensitivity to change and prediction of global change for the Alzheimer's Questionnaire.Alzheimer's research & therapy · 2015Article
- Depressive symptoms in healthy apolipoprotein E ε4 carriers and noncarriers: a longitudinal study.The Journal of clinical psychiatry · 2013Article
- The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2013Review
- Depressive Symptoms in Clinical and Incipient Alzheimer's Disease.Neurodegenerative disease management · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo evaluate the degree to which longitudinal stability of subsyndromal symptoms of depression (SSD) is associated with conversion to dementia in patients with mild cognitive impairment (MCI).
methodsData from 405 MCI participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study were analyzed. Participants were evaluated at baseline and 12-month intervals over 3 years. Participants were designated as MCI converters if dementia was diagnosed within 3 years or as cognitively stable MCI if dementia was not diagnosed during this interval. SSD were evaluated utilizing the 15-item Geriatric Depression Scale (GDS). Endorsement of specific SSD at baseline and the stability of SSD over 36 months were compared between the two MCI groups.
resultsBaseline symptom endorsement and stability of total GDS scores did not differentiate MCI groups. Worsening of four individual items from the GDS over time (memory problems, feelings of helplessness, loss of interest, and preference for staying at home) differentiated MCI converters from cognitively stable MCI (p < 0.05 for all). However, only increased endorsement of memory symptoms over time was associated with progression to dementia after controlling for other clinical variables (p = 0.05).
conclusionsSSD in MCI participants largely consist of cognitive symptoms and activity limitations, and the stability of SSD over time differentiated the MCI groups better than baseline endorsement of symptoms. However, the only significant predictor of conversion to dementia was increased endorsement of memory problems, which likely represents insight into cognitive problems more than depressive symptomatology in MCI individuals.
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