ArticleInternational journal of clinical pharmacy2011
Implementing a pharmacist-led sequential antimicrobial therapy strategy: a controlled before-and-after study.
Article in International journal of clinical pharmacy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Evaluation of a clinical pharmacist consultation service for patients with infectious diseases in China: a systematic review and meta-analysis.European journal of hospital pharmacy : science and practice · 2020Pooled it
- Value of hospital antimicrobial stewardship programs [ASPs]: a systematic review.Antimicrobial resistance and infection control · 2019Pooled it
- Economic evaluations of clinical pharmacist interventions on hospital inpatients: a systematic review of recent literature.International journal of clinical pharmacy · 2014Pooled it
- A sticker reminder intervention to promote intravenous-to-oral fluoroquinolone conversion: a cluster-randomized controlled trial.BMC infectious diseases · 2026Trial
- Single- and multiple-dose pharmacokinetics and absolute bioavailability of tedizolid.Pharmacotherapy · 2014Trial
- The effectiveness of intravenous (IV) to oral (PO) antibiotic switch (IVOS) interventions in managing community- and hospital-acquired pneumonia-a systematic review.JAC-antimicrobial resistance · 2026Review
- Antimicrobial stewardship in Ireland (2010-2021): a scoping review.BMC health services research · 2026Article
- Comparison of length of stay in community-acquired pneumonia patients who fit protocol for pharmacy driven de-escalation of ceftriaxone to standard of care.Exploratory research in clinical and social pharmacy · 2025Article
- Impact of the ABxSG Mobile Application on Antibiotic Prescribing: An Interrupted Time Series Study.Antibiotics (Basel, Switzerland) · 2025Article
- Harvesting the low-hanging fruit? Comparative assessment of intravenous to oral route antimicrobial conversion policy implementation.Infection control and hospital epidemiology · 2023Article
- Exploring Antimicrobial Stewardship Influential Interventions on Improving Antibiotic Utilization in Outpatient and Inpatient Settings: A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2022Review
- The Impact of a Pharmacist-Led Intravenous to Oral Switch of Metronidazole: A Before-and-After Study.Antibiotics (Basel, Switzerland) · 2022Article
- Utilizing Pharmacists to Optimize Medication Management Strategies During the COVID-19 Pandemic.Journal of pharmacy practice · 2022Article
- Interprofessional Collaboration between ICU Physicians, Staff Nurses, and Hospital Pharmacists Optimizes Antimicrobial Treatment and Improves Quality of Care and Economic Outcome.Antibiotics (Basel, Switzerland) · 2022Article
- Impact of a Multifaceted Pharmacist-Led Intervention on Antimicrobial Stewardship in a Gastroenterology Ward: A Segmented Regression Analysis.Frontiers in pharmacology · 2020Article
- The Clinical Pharmacist-Led Consultation for Infectious Diseases in Guizhou Province, China: A Survey Among Hospital Pharmacies.Frontiers in pharmacology · 2020Article
- Clinical outcome of pharmacist-led prospective audit with intervention and feedback after expansion from patients using specific antibiotics to those using whole injectable antibiotics.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Evaluation of the Effectiveness of Clinical Pharmacists' Consultation in the Treatment of Infectious Diseases: A Single-Arm, Prospective Cohort Study.Frontiers in pharmacology · 2019Article
- Optimizing compliance with surgical antimicrobial prophylaxis guidelines in patients undergoing gastrointestinal surgery at a referral teaching hospital in southern Iran: clinical and economic impact.Infection and drug resistance · 2019Article
- Evidence of clinical and economic impact of pharmacist interventions related to antimicrobials in the hospital setting.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledSequential antimicrobial therapy is an important part of antimicrobial stewardship and intends to improve the timeliness of switch to oral antimicrobials. The aim of this study was to assess the impact of the introduction of guidelines and criteria for switching to oral antimicrobials.
settingThe study was conducted in a 753-bed academic hospital in Ireland.
methodsThe study was prospective and of controlled before and after design. Patients admitted under the care of a medical consultant were screened for inclusion. The study was divided into pre-intervention and post-intervention phases. Patients admitted and prescribed IV antimicrobials were enrolled into either a study group or control group. Post-intervention, the intervention to the study group consisted of application of stickers and criteria for switch to oral antimicrobial therapy to the drug chart. Pre-intervention in the study group and in both phases in the control group, conventional practice of clinical pharmacists reviewing drug charts and contacting prescribers to discuss a switch to an oral antimicrobial continued. The duration of intravenous treatment, the timeliness of switch to oral therapy, length of stay and cost savings were measured.
main outcome measureThe duration of intravenous antimicrobial therapy in the pre-intervention and post-intervention phases in both study and control groups.
resultsPre-intervention, 85 courses of IV antimicrobials were prescribed to study group patients, compared to 60 in the control group. Post-intervention, there were 92 courses in the study group and 53 in the control group. The duration of IV antimicrobial treatment reduced significantly in the study group post-intervention, compared to the control group (P = 0.02). The timeliness of the switch also improved significantly in the study group post-intervention (P = 0.017). No improvement occurred in the control group. The median length of stay was not reduced post-intervention. Antimicrobial costs reduced by a mean of €6.41 in the study group post-intervention.
conclusionThis controlled before and after study demonstrates successful implementation of a pharmacist-led antimicrobial stewardship strategy. Duration of IV antimicrobial treatment reduced significantly and the timeliness of switch significantly improved. This study may be used as a template for the introduction of further pharmacist-led antimicrobial stewardship initiatives.
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