Evidence map›Paper›PMID 21744182›Full record

ReviewJournal of clinical immunology2011

Lymphoid proliferations of indeterminate malignant potential arising in adults with common variable immunodeficiency disorders: unusual case studies and immunohistological review in the light of possible causative events.

Sara Pereira da Silva, Elena Resnick, Mary Lucas, Jennifer Lortan, Smita Patel, Charlotte Cunningham-Rundles, Kevin Gatter, Qingyan Liu, Elaine S Jaffe, Helen Chapel

Abstract readCase ReportsReview
In one paragraph

Review in Journal of clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Chronic Lung Disease in Primary Antibody Deficiency: Diagnosis and Management.Immunology and allergy clinics of North America · 2020
    Review
  9. Review
  10. Common variable immune deficiency: case studies.Hematology. American Society of Hematology. Education Program · 2019
    Article
  11. Review
  12. Article
  13. Primary B-cell immunodeficiencies.Human immunology · 2019
    Review
  14. Common Variable Immunodeficiency and Liver Involvement.Clinical reviews in allergy & immunology · 2018
    Review
  15. Article
  16. Article
  17. Immune deficiency: changing spectrum of pathogens.Clinical and experimental immunology · 2015
    Article
  18. Article
  19. Pulmonary radiologic findings in common variable immunodeficiency: clinical and immunological correlations.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2014
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sara Pereira da SilvaImmunoallergology Department, Santa Maria Hospital, Lisbon, Portugal.
Elena Resnick
Mary Lucas
Jennifer Lortan
Smita Patel
Charlotte Cunningham-Rundles
Kevin Gatter
Qingyan Liu
Elaine S Jaffe
Helen Chapel

Funding

Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8M
Lymphoma Disease Discovery and DefintionZIASC000550 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI JAFFE, ELAINE · 2009 to 2025
$16.9M
Hematopathology DiagnosisZIABC011070 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JAFFE, ELAINE · 2009 to 2025
$14.5M
Hematopathology FellowshipZIEBC011241 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JAFFE, ELAINE · 2009 to 2025
$11.1M
Resources to Assist Investigations in Primary Immunodeficiency Diseases (U24)U24AI086037 · NIAID · IMMUNE DEFICIENCY FOUNDATION · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2010 to 2019
$6.5M
TARGETING PRIMARY IMMUNODEFICIENCY AMONG MINORITIESR18AI048693 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2000 to 2016
$6.2M
Exposporium determinants of Bacillus anthracisR21AI101093 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI STEWART, GEORGE C. · 2012 to 2013
$390k
NIAID NIH HHS AI 101093NIAID NIH HHS AI-467320NIAID NIH HHS AI-48693NIAID NIH HHS P01 AI061093NIAID NIH HHS R18 AI048693NIAID NIH HHS R21 AI101093NIAID NIH HHS U24 AI086037
6 · The paper itself

Abstract

Patients with common variable immunodeficiency disorders (CVIDs) who developed B cell lymphoproliferation of indeterminate malignant potential are described in order to raise a discussion of the relationship between infection and lymphoproliferation in infection prone patients. Those with CVID are at risk of developing either polyclonal or monoclonal lymphoproliferation in part due to the dysregulation of their adaptive immune systems. The aetiologies of the lymphoproliferations are unknown but intriguing; the relevance of infection being particularly problematic. The patients described here demonstrate variability in preceding infection, age at presentation, response to antibiotics and other types of therapy as well as outcome. The question of treatment is also controversial; issues include whether antibiotics or chemotherapy are the first line of therapy in all patients and whether transformation to aggressive B cell malignancy is inevitable or depends on other factors and if so, the length of time for such progression.

Indexed as

AdultAgedAspergillosisAspergillus fumigatusAutoimmunityB-LymphocytesCell Transformation, NeoplasticCell Transformation, ViralCommon Variable ImmunodeficiencyDiagnosis, DifferentialEpstein-Barr Virus InfectionsFatal OutcomeFemaleHerpesvirus 4, HumanHumansLung

Identifiers

PMID21744182
PMCPMC3428024

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.