ReviewHead and neck pathology2012
Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data.
Review in Head and neck pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
106 citing papers in PubMed, 262 citations in OpenAlex.
- Maxillary sinus myoepithelioma: a case report.International journal of surgery case reports · 2026Article
- A case report of pleomorphic adenoma in a 27-year-old female.Radiology case reports · 2026Article
- An Uncommon Site for a Common Tumor: Pleomorphic Adenoma of the Accessory Parotid Gland.Cureus · 2026Article
- A 67-year-old man with metastatic carcinoma ex pleomorphic adenoma of the parotid gland: case report and review of the literature.Journal of surgical case reports · 2026Article
- Molecular and Microenvironmental Mechanisms of Malignant Transformation in Benign Salivary Gland Tumors: Implications for Oral Squamous Cell Carcinoma.Diagnostics (Basel, Switzerland) · 2026Review
- Massive Recurrent Parotid Carcinoma in a 90-Year-Old Patient: A Case Report and Review of Management Strategies.Cureus · 2026Article
- Pedunculated Pleomorphic Adenoma With Adipocytic Metaplasia of the Hard Palate: A Case Report.Clinical medicine insights. Case reports · 2026Article
- Apocrine Ductal CarcinomaSurgical case reports · 2026Article
- Evaluation of Deep Learning Convolutional Neural Networks for Classification of Carcinoma Ex Pleomorphic Adenoma and Pleomorphic Adenoma in Whole-Slide Images.Head and neck pathology · 2025Article
- Case Report: Carcinoma Ex-Pleomorphic Adenoma With Concurrent Submandibular Gland Lithiasis-A Rare Association With Potential Pathophysiological Implications.Clinical case reports · 2025Article
- Primary temporal bone osteosarcoma presenting as a parotid tumor: A case report with diagnostic challenges.Radiology case reports · 2025Article
- Enormous high-grade carcinoma arising from a pleomorphic adenoma in the parotid gland: A case report.International journal of surgery case reports · 2025Article
- Diagnostic Pitfalls in Fine Needle Aspiration of Pleomorphic Adenoma: Degenerative Changes in Myoepithelial Cells as Malignant and PLAG1 False Negativity.Diagnostic cytopathology · 2025Article
- Gigantic, Sixteen-Pound Carcinoma Ex Pleomorphic Adenoma of the Neck.Clinical case reports · 2025Article
- Challenges in the Management of Giant Carcinoma Ex-Pleiomorphic Adenoma of the Parotid Gland in a Single Tertiary Center.Medicina (Kaunas, Lithuania) · 2024Article
- Clinical and Morphological Aspects of Aggressive Salivary Gland Mixed Tumors: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
- Article
- Pleomorphic Adenoma with a Novel Gene Rearrangement-LINC01606::PLAG1.Head and neck pathology · 2024Review
- Article
- Assessment of synthetic MRI to distinguish Warthin's tumor from pleomorphic adenoma in the parotid gland: comparison of two methods of positioning the region of interest for synthetic relaxometry measurement.Frontiers in oncology · 2024Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carcinoma ex pleomorphic adenoma (Ca ex PA) is a carcinoma arising from a primary or recurrent benign pleomorphic adenoma. It often poses a diagnostic challenge to clinicians and pathologists. This study intends to review the literature and highlight the current clinical and molecular perspectives about this entity. The most common clinical presentation of CA ex PA is of a firm mass in the parotid gland. The proportion of adenoma and carcinoma components determines the macroscopic features of this neoplasm. The entity is difficult to diagnose pre-operatively. Pathologic assessment is the gold standard for making the diagnosis. Treatment for Ca ex PA often involves an ablative surgical procedure which may be followed by radiotherapy. Overall, patients with Ca ex PA have a poor prognosis. Accurate diagnosis and aggressive surgical management of patients presenting with Ca ex PA can increase their survival rates. Molecular studies have revealed that the development of Ca ex PA follows a multi-step model of carcinogenesis, with the progressive loss of heterozygosity at chromosomal arms 8q, then 12q and finally 17p. There are specific candidate genes in these regions that are associated with particular stages in the progression of Ca ex PA. In addition, many genes which regulate tumour suppression, cell cycle control, growth factors and cell-cell adhesion play a role in the development and progression of Ca ex PA. It is hopeful that these molecular data can give clues for the diagnosis and management of the disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.