ArticleJournal of materials science. Materials in medicine2011
Oxygen consumption, acidification and migration capacity of human primary osteoblasts within a three-dimensional tantalum scaffold.
Article in Journal of materials science. Materials in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- 3D printed scaffolds regulated by neural-bone metabolic coupling promote bone unit regeneration.Bioactive materials · 2026Article
- Advanced Ti-Nb-Ta Alloys for Bone Implants with Improved Functionality.Journal of functional biomaterials · 2024Article
- Hydrogel microspheres for bone regeneration through regulation of the regenerative microenvironment.Biomaterials translational · 2024Review
- Research progress and clinical translation of three-dimensional printed porous tantalum in orthopaedics.Biomaterials translational · 2023Review
- Decellularized xenogenic bone graft for repair of segmental bone defect in rabbits.Iranian journal of veterinary research · 2022Article
- The Cellular Choreography of Osteoblast Angiotropism in Bone Development and Homeostasis.International journal of molecular sciences · 2021Review
- Radially patterned transplantable biodegradable scaffolds as topographically defined contact guidance platforms for accelerating bone regeneration.Journal of biological engineering · 2021Article
- Early pH Changes in Musculoskeletal Tissues upon Injury-Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH.International journal of molecular sciences · 2020Article
- Biomaterials for bone tissue engineering scaffolds: a review.RSC advances · 2019Review
- Reconstructing Bone with Natural Bone Graft: A Review of In Vivo Studies in Bone Defect Animal Model.Nanomaterials (Basel, Switzerland) · 2018Review
- Effects of interfacial micromotions on vitality and differentiation of human osteoblasts.Bone & joint research · 2018Article
- Thin magnesium layer confirmed as an antibacterial and biocompatible implant coating in a co‑culture model.Molecular medicine reports · 2017Article
- Three-dimensional Printed Scaffolds with Gelatin and Platelets EnhanceChinese medical journal · 2016Article
- 3 dimensional cell cultures: a comparison between manually and automatically produced alginate beads.Cytotechnology · 2016Article
- Co-Culture of S. epidermidis and Human Osteoblasts on Implant Surfaces: An Advanced In Vitro Model for Implant-Associated Infections.PloS one · 2016Article
- Ratiometric Organic Fibers for Localized and Reversible Ion Sensing with Micrometer-Scale Spatial Resolution.Small (Weinheim an der Bergstrasse, Germany) · 2015Article
- Biocompatibility and osteogenic properties of porous tantalum.Experimental and therapeutic medicine · 2015Article
- Cellular Nutrition in Complex Three-Dimensional Scaffolds: A Comparison between Experiments and Computer Simulations.International journal of biomaterials · 2015Article
- Noninvasive Oxygen Monitoring in Three-Dimensional Tissue Cultures Under Static and Dynamic Culture Conditions.BioResearch open access · 2015Article
- Local delivery of rhVEGF165 through biocoated nHA/coral block grafts in critical-sized dog mandible defects: a histological study at the early stages of bone healing.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major clinical problem within synthetic, large-scaled scaffolds is the insufficient nutrient supply resulting in inhomogeneous cell proliferation and differentiation. The aim of this study was to analyse pH value, oxygen consumption and migration of human osteoblasts within a 3D tantalum scaffold, clinically used for larger bone defects. After 24 h the oxygen concentration within the scaffold decreased significantly and remained low during incubation. Monitoring of the pH value inside the tantalum scaffold showed a slightly acidification under static culture conditions. However, cell migration within the 3D scaffold was detected. Hence, in clinical application it can be assumed that porous tantalum scaffolds can be settled by osteoblasts under critical oxygen and nutrient supply. In general, monitoring of cell migration, oxygen consumption and acidification can be a suitable instrument for creating advanced 3D bone scaffolds.
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