ArticleMolecular and cellular biochemistry2011
Poly(I:C) induce bone marrow precursor cells into myeloid-derived suppressor cells.
Article in Molecular and cellular biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Immune Modulation by Myeloid-Derived Suppressor Cells in Diabetic Kidney Disease.International journal of molecular sciences · 2022Review
- CD14Gut · 2018Article
- Paradoxical myeloid-derived suppressor cell reduction in the bone marrow of SIV chronically infected macaques.PLoS pathogens · 2017Article
- The Role of Myeloid-Derived Suppressor Cells in Viral Infection.Viral immunology · 2017Review
- Monocytic Myeloid-Derived Suppressor Cells in Chronic Infections.Frontiers in immunology · 2017Review
- Phenotype, development, and biological function of myeloid-derived suppressor cells.Oncoimmunology · 2016Review
- Myeloid derived suppressor cells in physiological and pathological conditions: the good, the bad, and the ugly.Immunologic research · 2013Review
- Twist and miR-34a are involved in the generation of tumor-educated myeloid-derived suppressor cells.International journal of molecular sciences · 2013Article
- Myeloid-derived suppressor cells: the dark knight or the joker in viral infections?Immunological reviews · 2013Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DC) and myeloid-derived suppressor cells (MDSC) are important cells involved in immune response. DC can be generated from mouse bone marrow (BM) in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-4. Recent studies have revealed that combined treatment of bone marrow MDSC with LPS plus IFN-γ inhibited the DC development but enhanced MDSC functions, such as NO release and T cell suppression. In our study, bone marrow precursor cells cultures in GM-CSF and IL-4 were treated with poly(I:C) through the culture, Gr1(+)CD11b(+) cells with MDSC functions, such as NO release and T cell suppression were accumulated in the culture system. Then the similar phenomenon was observed in the vesicular stomatitis virus infection in vivo. In conclusion, we demonstrated that the bone marrow precursor cells in the presence of GM-CSF and IL-4 can differentiate into MDSC, which is dependent on the dynamic of interaction with poly(I:C).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.