ReviewJournal of assisted reproduction and genetics2011
Preimplantation genetic screening: does it help or hinder IVF treatment and what is the role of the embryo?
Review in Journal of assisted reproduction and genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Elevated contractility drives implantation failure in mouse embryos from aged females.Nature cell biology · 2026Article
- Retrospective Analysis of 1168 Cases of Ovular Decidual Tissue from First-Trimester Abortions: Proposal for a Histopathological Diagnostic Framework.Diagnostics (Basel, Switzerland) · 2026Article
- A mechanical origin for implantation defects in embryos from aged females.bioRxiv : the preprint server for biology · 2025Article
- DNA Content in Embryonic Extracellular Vesicles Is Independent of the Apoptotic Rate in Bovine Embryos Produced In Vitro.Animals : an open access journal from MDPI · 2024Article
- From Diagnosis to Treatment: Comprehensive Care by Reproductive Urologists in Assisted Reproductive Technology.Medicina (Kaunas, Lithuania) · 2023Review
- Article
- Do patients who achieve pregnancy using IVF-PGS do the recommended genetic diagnostic testing in pregnancy?Journal of assisted reproduction and genetics · 2018Article
- Application of microfluidic technologies to human assisted reproduction.Molecular human reproduction · 2017Review
- Preimplantation genetics and other reproductive options in Huntington disease.Handbook of clinical neurology · 2017Review
- The state of "freeze-for-all" in human ARTs.Journal of assisted reproduction and genetics · 2016Review
- A simple, less invasive stripper micropipetter-based technique for day 3 embryo biopsy.Fertility research and practice · 2016Article
- Reduction of multiple pregnancies in the advanced maternal age population after implementation of an elective single embryo transfer policy coupled with enhanced embryo selection: pre- and post-intervention study.Human reproduction (Oxford, England) · 2015Article
- Comprehensive chromosome analysis of blastocysts before implantation using array CGH.Molecular cytogenetics · 2013Article
- A review of, and commentary on, the ongoing second clinical introduction of preimplantation genetic screening (PGS) to routine IVF practice.Journal of assisted reproduction and genetics · 2012Review
- Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study.Molecular cytogenetics · 2012Article
- Challenges of Genetic Screening of In Vitro Fertilized Human Embryos Using Current Technologies.Journal of reproduction & infertilityArticle
- Successful birth of South India's first twins after preimplantation genetic screening of embryos.Journal of human reproductive sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite an ongoing debate over its efficacy, preimplantation genetic screening (PGS) is increasingly being used to detect numerical chromosomal abnormalities in embryos to improve implantation rates after IVF. The main indications for the use of PGS in IVF treatments include advanced maternal age, repeated implantation failure, and recurrent pregnancy loss. The success of PGS is highly dependent on technical competence, embryo culture quality, and the presence of mosaicism in preimplantation embryos. Today, cleavage stage biopsy is the most commonly used method for screening preimplantation embryos for aneuploidy. However, blastocyst biopsy is rapidly becoming the more preferred method due to a decreased likelihood of mosaicism and an increase in the amount of DNA available for testing. Instead of using 9 to 12 chromosome FISH, a 24 chromosome detection by aCGH or SNP microarray will be used. Thus, it is advised that before attempting to perform PGS and expecting any benefit, extended embryo culture towards day 5/6 should be established and proven and the clinical staff should demonstrate competence with routine competency assessments. A properly designed randomized control trial is needed to test the potential benefits of these new developments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.