ArticleFrontiers in systems neuroscience2011
Functional properties of striatal fast-spiking interneurons.
Article in Frontiers in systems neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed.
- Role of fast-spiking interneurons in modulating across-trial variability and within-trial correlations in the striatum.PLoS computational biology · 2026Article
- Accumbal calcium-permeable AMPA receptors orchestrate neuronal ensembles underlying social attachment.Nature communications · 2026Article
- Mu-opioid and nociceptin receptors show divergent, cell-type-specific actions in the mesocorticolimbic reward system in opioid use disorder.Frontiers in cellular neuroscience · 2026Review
- Learning-dependent 4 Hz synchronization in the posterior striatum, lateral geniculate nucleus, and visual cortex.iScience · 2025Article
- Optogenetic Mapping of Rhythmic Phase-Dependent Excitability in the Mouse Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Pallidal Deep Brain Stimulation Enhances Habitual Behavior in a Neuro-Computational Basal Ganglia Model During a Reward Reversal Learning Task.The European journal of neuroscience · 2025Article
- Cell-type-specific auditory responses in the striatum are shaped by feedforward inhibition.Cell reports · 2025Article
- Article
- Striatal function scrutinized through the PAN-TAN-FSI triumvirate.Frontiers in cellular neuroscience · 2025Review
- Single nucleus RNA-sequencing reveals transcriptional synchrony across different relationships.bioRxiv : the preprint server for biology · 2024Article
- Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior.Nature communications · 2024Article
- Dopamine transients follow a striatal gradient of reward time horizons.Nature neuroscience · 2024Article
- Article
- Updating the striatal-pallidal wiring diagram.Nature neuroscience · 2024Review
- The roles of surround inhibition for the intrinsic function of the striatum, analyzed in silico.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Temporal Signature of Task-Specificity in Isolated Focal Laryngeal Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Reward expectation enhances action-related activity of nigral dopaminergic and two striatal output pathways.Communications biology · 2023Article
- Striatal ensemble activity in an innate naturalistic behavior.bioRxiv : the preprint server for biology · 2023Article
- Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice.Nature communications · 2022Article
- Article
27 more citing papers are in PubMed but not listed here.
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Abstract
Striatal fast-spiking interneurons (FSIs) have a major influence over behavioral output, and a deficit in these cells has been observed in dystonia and Tourette syndrome. FSIs receive cortical input, are coupled together by gap junctions, and make perisomatic GABAergic synapses onto many nearby projection neurons. Despite being critical components of striatal microcircuits, until recently little was known about FSI activity in behaving animals. Striatal FSIs are near-continuously active in awake rodents, but even neighboring FSIs show uncorrelated activity most of the time. A coordinated "pulse" of increased FSI firing occurs throughout striatum when rats initiate one chosen action while suppressing a highly trained alternative. This pulse coincides with a drop in globus pallidus population activity, suggesting that pallidostriatal disinhibition may have a important role in timing or coordinating action execution. In addition to changes in firing rate, FSIs show behavior-linked modulation of spike timing. The variability of inter-spike intervals decreases markedly following instruction cues, and FSIs also participate in fast striatal oscillations that are linked to rewarding events and dopaminergic drugs. These studies have revealed novel and unexpected properties of FSIs, that should help inform new models of striatal information processing in both normal and aberrant conditions.
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