Evidence map›Paper›PMID 21743780›Full record

ArticleCurrent trends in immunology2009

THE MULTIFACETED ROLE OF T CELL-MEDIATED IMMUNITY IN PATHOGENESIS AND RESISTANCE TO MYCOPLASMA RESPIRATORY DISEASE.

Nicole A Dobbs, Adam N Odeh, Xiangle Sun, Jerry W Simecka

Open access · greenAbstract read
In one paragraph

Article in Current trends in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Evaluation ofInfection and immunity · 2025
    Article
  4. Review
  5. Bacteria Endocarditis Caused byComparative medicine · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Immune Evasion ofPathogens (Basel, Switzerland) · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Nicole A DobbsDepartment of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107.
Adam N Odeh
Xiangle Sun
Jerry W Simecka
Bipar · FRUniversity of North Texas · USUniversity of North Texas Health Science Center · US

Funding

T CELL SUBSETS IN MURINE MYCOPLASMA RESPIRATORY DISEASER01AI042075 · NIAID · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI SIMECKA, JERRY W · 1999 to 2010
$1.7M
Dendritic cells &immunity in mycoplasma pneumoniaR01HL069431 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI SIMECKA, JERRY W · 2004 to 2007
$1.2M
NHLBI NIH HHS R01 HL069431NIAID NIH HHS R01 AI042075
6 · The paper itself

Abstract

Mycoplasma respiratory diseases have a significant impact on the economy, health and wildlife. The hallmark of these diseases is the persistence of the mycoplasma infections and chronic inflammatory responses associated with the airways. There is still much that needs to be understood about the immune mechanisms involved in mycoplasma disease and resistance from infection. It is clear that immune responses can contribute to the generation of inflammatory lesions in mycoplasma respiratory disease, as well as provide protection from infection and extrapulmonary dissemination of the organisms. The evolution of this lung disease is under the control innate immune mechanisms and the contrasting effects of different T cell populations. The mechanisms of immunity involved in mycoplasma diseases are multifaceted, and a fascinating story of its complexity is being uncovered. Research in mycoplasma respiratory diseases have underscored the idea that immunity along the respiratory tract against infectious agents is a dynamic process and involves a network of cellular and cytokine signals that determine the type of responses generated, and ultimately, the outcome of infection. The aim of this article is to present on overview of our work on mycoplasma disease and immunity, focusing on the interactions and regulation of T cell responses that influence disease pathogenesis. We will first provide an overview of immune mechanisms involved in controlling infection and participate in the generation of T cell responses, and the role of T cell populations in generating protection and contributing to lesion development will be discussed.

Identifiers

PMID21743780
PMCPMC3131222
OpenAlexW2308256224

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.