ArticleChemical senses2011
Effect of chorda tympani nerve transection on salt taste perception in mice.
Article in Chemical senses, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Gustatory and olfactory-guided responsiveness to maltodextrin solutions in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Homeostatic Reinforcement Theory Accounts for Sodium Appetitive State- and Taste-Dependent Dopamine Responding.Nutrients · 2023Article
- Relationship between subjective taste sensations and taste strip test in patients with taste disorders with and without burning mouth syndrome.Journal of dental sciences · 2022Article
- Recovery of sweet taste preference in adult rats following bilateral chorda tympani nerve transection.PeerJ · 2022Article
- Innate and acquired tolerance to bitter stimuli in mice.PloS one · 2018Article
- Lemierre Syndrome Associated with Ipsilateral Recurrent Laryngeal Nerve Palsy: A Case Report and Review.NMC case report journal · 2016Article
- Salt appetite is reduced by a single experience of drinking hypertonic saline in the adult rat.PloS one · 2014Article
- A/J and C57BL/6J mice differ in chorda tympani responses to NaCl.Neuroscience research · 2013Article
- NaCl taste thresholds in 13 inbred mouse strains.Chemical senses · 2012Article
- Chorda tympani nerve modulates the rat's avoidance of calcium chloride.Physiology & behavior · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Effects of gustatory nerve transection on salt taste have been studied extensively in rats and hamsters but have not been well explored in the mouse. We examined the effects of chorda tympani (CT) nerve transection on NaCl taste preferences and thresholds in outbred CD-1 mice using a high-throughput phenotyping method developed in our laboratory. To measure taste thresholds, mice were conditioned by oral self-administration of LiCl or NaCl and then presented with NaCl concentration series in 2-bottle preference tests. LiCl-conditioned and control NaCl-exposed mice were given bilateral transections of the CT nerve (LiCl-CTX, NaCl-CTX) or were left intact as controls (LiCl-CNT, NaCl-CNT). After recovery from surgery, mice received a concentration series of NaCl (0-300 mM) in 48-h 2-bottle tests. CT transection increased NaCl taste thresholds in LiCl-conditioned mice and eliminated avoidance of concentrated NaCl in control NaCl-exposed mice. This demonstrates that in mice, the CT nerve is important for detection and recognition of NaCl taste and is necessary for the normal avoidance of high concentrations of NaCl. The results of this experiment also show that the method of high-throughput phenotyping of salt taste thresholds is suitable for detecting changes in the taste periphery in mouse genetic studies.
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