ArticleThe Plant cell2011
Distinct cell-autonomous functions of RETINOBLASTOMA-RELATED in Arabidopsis stem cells revealed by the Brother of Brainbow clonal analysis system.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 56 citations in OpenAlex.
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- Tracing meristem cell lineages during plant development and regeneration by the all-in-one CRE/LOX system.Plant methods · 2025Article
- Single-cell lineage tracing techniques in hematology: unraveling the cellular narrative.Journal of translational medicine · 2025Review
- Developmental cues are encoded by the combinatorial phosphorylation of Arabidopsis RETINOBLASTOMA-RELATED protein RBR1.The EMBO journal · 2024Article
- PAT1-type GRAS-domain proteins control regeneration by activating DOF3.4 to drive cell proliferation in Arabidopsis roots.The Plant cell · 2023Article
- An integrase toolbox to record gene-expression during plant development.Nature communications · 2023Article
- Multicolor strategies for investigating clonal expansion and tissue plasticity.Cellular and molecular life sciences : CMLS · 2022Review
- The hidden half comes into the spotlight: Peeking inside the black box of root developmental phases.Plant communications · 2022Review
- Auxin controls the division of root endodermal cells.Plant physiology · 2021Article
- Root stem cell niche networks: it's complexed! Insights from Arabidopsis.Journal of experimental botany · 2021Article
- Article
- Hormonal Regulation of Stem Cell Proliferation at theFrontiers in plant science · 2021Review
- Beyond What Your Retina Can See: Similarities of Retinoblastoma Function between Plants and Animals, from Developmental Processes to Epigenetic Regulation.International journal of molecular sciences · 2020Review
- An inducible genome editing system for plants.Nature plants · 2020Article
- Positional cues regulate dorsal organ formation in the liverwort Marchantia polymorpha.Journal of plant research · 2020Article
- A system-level mechanistic explanation for asymmetric stem cell fates: Arabidopsis thaliana root niche as a study system.Scientific reports · 2020Article
- Ectopic BASL Reveals Tissue Cell Polarity throughout Leaf Development in Arabidopsis thaliana.Current biology : CB · 2018Article
- Fruit shape diversity in the Brassicaceae is generated by varying patterns of anisotropy.Development (Cambridge, England) · 2016Article
- Defining Clonal Color in Fluorescent Multi-Clonal Tracking.Scientific reports · 2016Article
- The never-ending story: from pluripotency to plant developmental plasticity.Development (Cambridge, England) · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations that cause lethality in the gametophyte phase pose a major challenge for studying postfertilization gene function. When both male and female haploid cells require a functional gene copy, null alleles cause developmental arrest before the formation of the zygote, precluding further investigation. The Arabidopsis thaliana Rb homolog RETINOBLASTOMA-RELATED (RBR) has an important function in the stem cell niche, but its requirement in both male and female gametophytes has prevented full loss-of-function studies. To circumvent this obstacle, we designed a clonal deletion system named BOB (Brother of Brainbow) in which null mutant sectors marked by double fluorescence are generated in a fully complemented wild-type background. In this system, both copies of a complementing RBR transgene are eliminated by tissue-specific and inducible CRE expression, and homozygous mutant clones can be distinguished visually. Since mutant sectors can be produced in a homozygous, rather than a heterozygous, background, this system facilitates clonal deletion analysis not only for gametophytic lethal alleles but also for any type of mutation. Using the BOB system, we show that RBR has unique cell-autonomous functions in different cell types within the root stem cell niche.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.