ArticleApplied and environmental microbiology2011
Staphylococcus aureus host range and human-bovine host shift.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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71 citing papers in PubMed, 144 citations in OpenAlex.
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- Epidemiological investigation and antimicrobial sensitivity of Staphylococcus aureus in dairy farms of selected towns in Western oromia, Ethiopia.BMC veterinary research · 2025Article
- Longitudinal Patterns in the Isolation and Antimicrobial Resistance of Bovine Mastitis-Causing Bacteria in Ireland.Antibiotics (Basel, Switzerland) · 2025Article
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- An observational study demonstrates human-adapted Staphylococcus aureus strains have a higher frequency of antibiotic resistance compared to cattle-adapted strains isolated from dairy farms making farmstead cheese.BMC veterinary research · 2024Observational
- Rapid Antibacterial Activity Assessment of Chimeric Lysins.International journal of molecular sciences · 2024Article
- The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2021-2022.EFSA journal. European Food Safety Authority · 2024Article
- WGS Analysis ofInfection and drug resistance · 2024Article
- spa Types and Staphylococcal Enterotoxin Production of Staphylococcus aureus Isolated from Wild Boar.Microbial ecology · 2023Article
- Virulence Mechanisms of Staphylococcal Animal Pathogens.International journal of molecular sciences · 2023Review
- Community-Acquired Methicillin-ResistantDiagnostics (Basel, Switzerland) · 2023Article
- Molecular Characterization ofMicroorganisms · 2023Article
- Antibiotics Resistance and Adhesive Properties of ClinicalMicroorganisms · 2023Article
- Genome sequencing and comparative genomic analysis of bovine mastitis-associated Staphylococcus aureus strains from India.BMC genomics · 2023Article
- Current Limitations of Staph Infection Diagnostics, and the Role for VOCs in Achieving Culture-Independent Detection.Pathogens (Basel, Switzerland) · 2023Review
- Antimicrobial susceptibility of staphylococci from bovine milk samples in routine microbiological mastitis analysis in Finland.Frontiers in veterinary science · 2023Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus is a major agent of bovine mastitis. The concomitant emergence of pig-associated methicillin-resistant S. aureus (MRSA) in human carriage and infection requires a reexamination of the host range and specificity of human- and cow-associated S. aureus strains, something which has not been systematically studied previously. The genetic relatedness of 500 S. aureus isolates from bovine mastitis cases, 57 isolates from nasal carriage of farmers, and 133 isolates from nonfarmers was determined by amplified fragment length polymorphism (AFLP) analysis and spa typing. Multilocus sequence typing (MLST) was conducted on a subset of isolates to match AFLP clusters with MLST clonal complexes (CCs). This data set allowed us to study host range and host specificity and to estimate the extent of bovine-to-human transmission. The genotype compositions of S. aureus isolates from farmers and nonfarmers were very similar, while the mastitis isolates were quite distinct. Overall, transmission was low, but specific genotypes did show increased cow-to-human transmission. Unexpectedly, more than one-third of mastitis isolates belonged to CC8, a lineage which has not been considered to be bovine mastitis associated, but it is well known from human carriage and infection (i.e., USA300). Despite the fact that we did detect some transmission of other genotypes from cows to farmers, no transmission of CC8 isolates to farmers was detected, except for one tentative case. This was despite the close genetic relatedness of mastitis CC8 strains to nonfarmer carriage strains. These results suggest that the emergence of the new bovine-adapted genotype was due to a recent host shift from humans to cows concurrent with a loss of the ability to colonize humans. More broadly, our results indicate that host specificity is a lineage-specific trait that can rapidly evolve.
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