ArticleThe Journal of infectious diseases2011
Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in humoral immunity to smallpox vaccination in Caucasians and African Americans.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Identification of genetic variants of theAnnals of medicine · 2025Article
- Effect of the gut microbiome and inflammation-related proteins on oral leukoplakia: a Mendelian randomization study and mediation analysis.Frontiers in oncology · 2024Article
- Pilot genome-wide association study of antibody response to inactivated SARS-CoV-2 vaccines.Frontiers in immunology · 2022Article
- Effect of Serial Passage on the Pathogenicity and Immunogenicity of Vaccinia Virus LC16m8 Strain.Biology · 2021Review
- Factors That Influence the Immune Response to Vaccination.Clinical microbiology reviews · 2019Review
- The genetic prehistory of the Andean highlands 7000 years BP though European contact.Science advances · 2018Article
- An interaction quantitative trait loci tool implicates epistatic functional variants in an apoptosis pathway in smallpox vaccine eQTL data.Genes and immunity · 2016Article
- HLA alleles associated with the adaptive immune response to smallpox vaccine: a replication study.Human genetics · 2014Article
- Associations between race, sex and immune response variations to rubella vaccination in two independent cohorts.Vaccine · 2014Article
- IL-18 expression results in a recombinant vaccinia virus that is highly attenuated and immunogenic.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2014Article
- Characterization of humoral and cellular immunity to rubella vaccine in four distinct cohorts.Immunologic research · 2014Article
- Article
- Cytokine production associated with smallpox vaccine responses.Immunotherapy · 2014Review
- Genetic variation in IL18R1 and IL18 genes and Inteferon γ ELISPOT response to smallpox vaccination: an unexpected relationship.The Journal of infectious diseases · 2013Article
- Soft truncation thresholding for gene set analysis of RNA-seq data: application to a vaccine study.Scientific reports · 2013Article
- Race and sex-based differences in cytokine immune responses to smallpox vaccine in healthy individuals.Human immunology · 2013Article
- Article
- Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century.Seminars in immunology · 2013Review
- Variation between Populations in the Innate Immune Response to Vaccine Adjuvants.Frontiers in immunology · 2013Article
- Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIdentifying genetic factors that influence poxvirus immunity across races may assist in the development of better vaccines and approaches for vaccine development.
methodsWe performed an extensive candidate-gene genetic screen (across 32 cytokine and cytokine receptor genes) in a racially diverse cohort of 1056 healthy adults after a single dose of smallpox vaccine. Associations between single-nucleotide polymorphisms (SNPs)/haplotypes and vaccinia virus-specific neutralizing antibodies were assessed using linear regression methodologies.
resultsThe combined analysis identified 63 associations between candidate SNPs and antibody levels after smallpox vaccination with P < .05. Thirty-one of these were within the IL18R1 and IL18 genes. Five IL18R1 SNPs, including a coding synonymous polymorphism rs1035130 (Phe251Phe) and 2 promoter SNPs (rs6710885, rs2287037), all in linkage disequilibrium, were associated with significant variations in antibody levels in both Caucasians (P ≤ .016) and African Americans (P ≤ .025). Similarly, associations with 2 intronic IL18 SNPs (rs2043055 and rs5744280) were consistent in the Caucasian (P ≤ .023) and African American samples (P ≤ .014). Haplotype analysis revealed highly significant associations between IL18R1 haplotypes and vaccinia virus-specific antibody levels (P < .001, by combined analysis) that were consistent across races.
conclusionsOur study provides evidence for IL18 and IL18R1 genes as plausible genes regulating the humoral immune response to smallpox vaccine in both Caucasians and African Americans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.