ArticleThe Journal of infectious diseases2011
Early deaths during tuberculosis treatment are associated with depressed innate responses, bacterial infection, and tuberculosis progression.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Proteomic Immune Signatures of Severe HIV-Associated Tuberculosis in Sub-Saharan Africa: A Prospective, Multicenter Analysis From Uganda.Critical care explorations · 2026Observational
- Global, regional, and national economic value of reducing amenable tuberculosis mortality.Infectious Disease Modelling · 2026Article
- Article
- Treatment outcomes of pulmonary TB in adults in Indonesia.IJTLD open · 2025Article
- Factors associated with successful treatment outcomes among tuberculosis patients in a district municipality of Vhembe, Limpopo.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2025Article
- Article
- The First Differentiated TB Care Model From India: Delays and Predictors of Losses in the Care Cascade.Global health, science and practice · 2023Article
- Mathematical modelling and analysis of COVID-19 and tuberculosis transmission dynamics.Informatics in medicine unlocked · 2023Article
- Screening for Severe Illness at Diagnosis Has the Potential to Prevent Early TB Deaths: Programmatic Experience From Karnataka, India.Global health, science and practice · 2022Article
- Article
- Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil.Tropical medicine and health · 2021Article
- Tuberculosis deaths are predictable and preventable: Comprehensive assessment and clinical care is the key.Journal of clinical tuberculosis and other mycobacterial diseases · 2020Article
- COVID-19 and tuberculosis: A mathematical model based forecasting in Delhi, India.The Indian journal of tuberculosis · 2020Article
- Undernutrition and Mortality among Adult Tuberculosis Patients in Addis Ababa, Ethiopia.Advances in preventive medicine · 2020Article
- Clinical, microbiologic, and immunologic determinants of mortality in hospitalized patients with HIV-associated tuberculosis: A prospective cohort study.PLoS medicine · 2019Observational
- A Bayesian Approach to Understanding Sex Differences in Tuberculosis Disease Burden.American journal of epidemiology · 2018Article
- Mortality in Severe Human Immunodeficiency Virus-Tuberculosis Associates With Innate Immune Activation and Dysfunction of Monocytes.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- High mortality among tuberculosis patients on treatment in Nigeria: a retrospective cohort study.BMC infectious diseases · 2017Article
- Monocyte unresponsiveness and impaired IL1β, TNFα and IL7 production are associated with a poor outcome in Malawian adults with pulmonary tuberculosis.BMC infectious diseases · 2015Article
- Sepsis carries a high mortality among hospitalised adults in Malawi in the era of antiretroviral therapy scale-up: a longitudinal cohort study.The Journal of infection · 2015Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Up to 14% of Malawian adults die during the intensive phase of tuberculosis treatment. In a prospective cohort of 199 Malawian adults with microbiologically confirmed pulmonary tuberculosis, clinical and laboratory parameters were compared between those who died or deteriorated with those who had an uneventful recovery. Baseline tumor necrosis factor alpha responses to stimulation with heat-killed Mycobacterium tuberculosis and lipopolysaccharide were reduced among the 22 patients with poor outcome (P = .017). Low body mass index (P = .002) and elevated respiratory rate (P = .01) at tuberculosis diagnosis independently predicted poor outcome. Validation of a clinical score identifying high-risk individuals is warranted, together with further investigation of immunological derangements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.