ArticleNucleic acids research2011
Computational analysis of DNA replicases in double-stranded DNA viruses: relationship with the genome size.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Abundant and cosmopolitan lineage of cyanopodoviruses lacking a DNA polymerase gene.The ISME journal · 2023Article
- How different viruses perturb host cellular machinery via short linear motifs.EXCLI journal · 2023Review
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- Molecular Characterization of a DNA Polymerase fromInternational journal of molecular sciences · 2022Article
- Phage phiKZ-The First of Giants.Viruses · 2021Review
- Diversity and evolution of B-family DNA polymerases.Nucleic acids research · 2020Review
- Primer-Independent DNA Synthesis by a Family B DNA Polymerase from Self-Replicating Mobile Genetic Elements.Cell reports · 2017Article
- Three novel bacteriophages isolated from the East African Rift Valley soda lakes.Virology journal · 2016Article
- The logic of DNA replication in double-stranded DNA viruses: insights from global analysis of viral genomes.Nucleic acids research · 2016Article
- Self-synthesizing transposons: unexpected key players in the evolution of viruses and defense systems.Current opinion in microbiology · 2016Review
- Protein-protein interactions leading to recruitment of the host DNA sliding clamp by the hyperthermophilic Sulfolobus islandicus rod-shaped virus 2.Journal of virology · 2014Article
- Comprehensive analysis of DNA polymerase III α subunits and their homologs in bacterial genomes.Nucleic acids research · 2014Article
- Lateral gene transfer of family A DNA polymerases between thermophilic viruses, aquificae, and apicomplexa.Molecular biology and evolution · 2013Article
- A genetic approach to the development of new therapeutic phages to fight pseudomonas aeruginosa in wound infections.Viruses · 2012Review
- Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Genome duplication in free-living cellular organisms is performed by DNA replicases that always include a DNA polymerase, a DNA sliding clamp and a clamp loader. What are the evolutionary solutions for DNA replicases associated with smaller genomes? Are there some general principles? To address these questions we analyzed DNA replicases of double-stranded (ds) DNA viruses. In the process we discovered highly divergent B-family DNA polymerases in phiKZ-like phages and remote sliding clamp homologs in Ascoviridae family and Ma-LMM01 phage. The analysis revealed a clear dependency between DNA replicase components and the viral genome size. As the genome size increases, viruses universally encode their own DNA polymerases and frequently have homologs of DNA sliding clamps, which sometimes are accompanied by clamp loader subunits. This pattern is highly non-random. The absence of sliding clamps in large viral genomes usually coincides with the presence of atypical polymerases. Meanwhile, sliding clamp homologs, not accompanied by clamp loaders, have an elevated positive electrostatic potential, characteristic of non-ring viral processivity factors that bind the DNA directly. Unexpectedly, we found that similar electrostatic properties are shared by the eukaryotic 9-1-1 clamp subunits, Hus1 and, to a lesser extent, Rad9, also suggesting the possibility of direct DNA binding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.