Evidence map›Paper›PMID 21742224›Full record

ReviewCritical care clinics2011

Gene therapy for ALI/ARDS.

Xin Lin, David A Dean

Abstract readReview
In one paragraph

Review in Critical care clinics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Nanomedicine-Based Therapeutics to Combat Acute Lung Injury.International journal of nanomedicine · 2021
    Review
  7. Acetylharpagide Protects Mice fromMolecules (Basel, Switzerland) · 2020
    Article
  8. RNAi therapeutic strategies for acute respiratory distress syndrome.Translational research : the journal of laboratory and clinical medicine · 2019
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Nuclear medicine and biology · 2017
    Article
  14. Adult respiratory distress syndrome.Annals of the Royal College of Surgeons of England · 2017
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xin LinDepartment of Pediatrics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA.
David A Dean
University of Rochester · US

Funding

Electroporation-mediated Pulmonary Gene Transfer for Acute Lung InjuryR21HL092801 · NHLBI · UNIVERSITY OF ROCHESTER · PI DEAN, DAVID A · 2008 to 2012
$2.9M
Cytoplasmic trafficking of non-viral gene therapy vectorsR01EB009903 · NIBIB · UNIVERSITY OF ROCHESTER · PI DEAN, DAVID A · 2009 to 2017
$2.7M
Alveolar Epithelial Cell-Specific Gene Therapy PlasmidsR01HL081148 · NHLBI · UNIVERSITY OF ROCHESTER · PI DEAN, DAVID A · 2006 to 2010
$1.8M
DNA Nuclear Import Sequences for Cell-Specific Gene and Drug DeliveryR01GM094228 · NIGMS · UNIVERSITY OF ROCHESTER · PI DEAN, DAVID A · 2010 to 2013
$1.7M
NHLBI NIH HHS HL81148NHLBI NIH HHS HL92801NHLBI NIH HHS R01 HL081148NHLBI NIH HHS R21 HL092801NIBIB NIH HHS EB9903NIBIB NIH HHS R01 EB009903NIGMS NIH HHS GM94228NIGMS NIH HHS R01 GM094228
6 · The paper itself

Abstract

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by acute respiratory failure and are associated with diverse disorders. Gene therapy is a potentially powerful approach to treat diseases related to ALI/ARDS, and numerous viral and nonviral methods for gene delivery to the lung have been developed. Discussed are recent advances in the development of more efficient viral and nonviral gene transfer systems, and the current status of gene therapy applied to ALI/ARDS-associated pulmonary diseases is reviewed. With the development of more efficient gene therapy vectors, gene therapy is a promising strategy for clinical application.

Indexed as

Acute Lung InjuryGenetic TherapyGenetic VectorsHumansPneumoniaPulmonary AlveoliRespiratory Distress SyndromeSepsis

Identifiers

PMID21742224
PMCPMC3482940
OpenAlexW2019611732

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.