Evidence map›Paper›PMID 21742087›Full record

ReviewAmerican heart journal2011

Differential impact of race and risk factors on incidence of atrial fibrillation.

T David Gbadebo, Henry Okafor, Dawood Darbar

Open access · greenAbstract readReview
In one paragraph

Review in American heart journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. A novel gain-of-function mutationAmerican journal of cardiovascular disease · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Obstructive Sleep Apnea and Atrial Fibrillation: Honing in on Race-Specific Susceptibilities.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Effect of Digoxin Use Among Medicaid Enrollees With Atrial Fibrillation.Circulation. Arrhythmia and electrophysiology · 2017
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

T David GbadeboUniversity of Tennessee Erlanger Cardiology, UT College of Medicine, Chattanooga, TN, USA.
Henry Okafor
Dawood Darbar
Erlanger Health System · USMeharry Medical College · USVanderbilt University · US

Funding

PHARMACOGENOMICS OF ARRHYTHMIA THERAPYU01HL065962 · NHLBI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2001 to 2009
$24.8M
Pharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4M
Positional Cloning and Candidate Gene Approach to Familial Atrial FibrillationR01HL092217 · NHLBI · VANDERBILT UNIVERSITY · PI DARBAR, DAWOOD · 2009 to 2017
$2.9M
QT Interval Remodeling in Atrial FibrillationR01HL085690 · NHLBI · VANDERBILT UNIVERSITY · PI DARBAR, DAWOOD · 2008 to 2012
$1.9M
The Genetic Basis of Atrial FibrillationK23HL075266 · NHLBI · VANDERBILT UNIVERSITY · PI DARBAR, DAWOOD · 2005 to 2009
$745k
NHLBI NIH HHS HL65962NHLBI NIH HHS HL75266NHLBI NIH HHS K23 HL075266NHLBI NIH HHS R01 HL085690NHLBI NIH HHS R01 HL092217NHLBI NIH HHS U01 HL065962NHLBI NIH HHS U19 HL065962
6 · The paper itself

Abstract

Despite some common risk factors for atrial fibrillation (AF) being more prevalent among blacks, African Americans are increasingly being reported with lower prevalence and incidence of AF compared with whites. Contemporary studies have not provided a complete explanation for this apparent AF paradox in African Americans. Although many traditional and novel risk factors for AF have been identified, the role of ethnic-specific risk factors has not been examined. Whereas hypertension has been the most common risk factor associated with AF, coronary artery disease also plays an important role in AF pathophysiology in whites. Thereby, elucidating the role of ethnic-specific risk factors for AF may provide important insight into why African Americans are protected from AF or why whites are more prone to develop the arrhythmia. The link between AF susceptibility and genetic processes has only been recently uncovered. Polymorphisms in renin-angiotensin system genes have been characterized as predisposing to AF under certain environmental conditions. Several ion channel genes, signaling molecules, and several genetic loci have been linked with AF. Thereby, studies investigating genetic variants contributing to the differential AF risk in individuals of African American versus European ancestry may also provide important insight into the etiology of the AF paradox in blacks.

Indexed as

Racial GroupsAtrial FibrillationHumansIncidenceRisk FactorsUnited States

Identifiers

PMID21742087
PMCPMC3137277
OpenAlexW2034440918

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.