ArticleThe American journal of pathology2011
B4GALNT3 expression predicts a favorable prognosis and suppresses cell migration and invasion via β₁ integrin signaling in neuroblastoma.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Neuroblastoma cell growth and invasiveness is modulated by the activity of N-acetylglucosaminyltransferase-III.PloS one · 2026Article
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- Chaetocin inhibits the progression of neuroblastoma by targeting JAK2/STAT3 signaling pathway in SH-SY5Y cells.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Role of Wisteria floribunda agglutinin binding glycans in carcinogenesis and metastasis of cholangiocarcinoma.Histochemistry and cell biology · 2024Article
- Central Role of β-1,4-GalT-V in Cancer Signaling, Inflammation, and Other Disease-Centric Pathways.International journal of molecular sciences · 2023Review
- TMTC1 promotes invasiveness of ovarian cancer cells through integrins β1 and β4.Cancer gene therapy · 2023Article
- Review
- Biosynthesis and Biological Significances of LacdiNAc Group onBiomolecules · 2022Review
- Current insights into the metastasis of epithelial ovarian cancer - hopes and hurdles.Cellular oncology (Dordrecht, Netherlands) · 2020Review
- LacdiNAcylation of N-glycans in MDA-MB-231 human breast cancer cells results in changes in morphological appearance and adhesive properties of the cells.Histochemistry and cell biology · 2020Article
- Profiling of different pancreatic cancer cells used as models for metastatic behaviour shows large variation in their N-glycosylation.Scientific reports · 2017Article
- The lactoferricin B-derived peptide, LfB17-34, induces melanogenesis in B16F10 cells.International journal of molecular medicine · 2017Article
- Article
- Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma.Journal of hematology & oncology · 2016Review
- New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma.Oncotarget · 2015Article
- The "next-generation" knowledge of papillary thyroid carcinoma.Cell cycle (Georgetown, Tex.) · 2015Review
- JARID1B Expression Plays a Critical Role in Chemoresistance and Stem Cell-Like Phenotype of Neuroblastoma Cells.PloS one · 2015Article
- Trefoil factor family domains represent highly efficient conformational determinants for N-linked N,N'-di-N-acetyllactosediamine (LacdiNAc) synthesis.The Journal of biological chemistry · 2014Article
- Wisteria floribunda agglutinin-binding glycan expression is decreased in endometriomata.Reproductive biology and endocrinology : RB&E · 2014Article
- Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
β1,4-N-acetylgalactosaminyltransferase III (B4GALNT3) promotes the formation of GalNAcβ1,4GlcNAc (LacdiNAc or LDN). Drosophila β1,4-N-acetylgalactosaminyltransferase A (B4GALNTA) contributes to the synthesis of LDN, which helps regulate neuronal development. In this study, we investigated the expression and role of B4GALNT3 in human neuroblastoma (NB). We used IHC analysis to examine 87 NB tumors, and we identified correlations between B4GALNT3 expression and clinicopathologic factors, including patient survival. Effects of recombinant B4GALNT3 on cell behavior and signaling were studied in SK-N-SH and SH-SY5Y NB cells. Increased expression of B4GALNT3 in NB tumors correlated with a favorable histologic profile (P < 0.001, χ² test) and early clinical staging (P = 0.041, χ² test) and was a favorable prognostic factor for survival as evaluated by univariate and multivariate analyses. Reexpression of B4GALNT3 in SK-N-SH and SH-SY5Y cells suppressed cell proliferation, colony formation, migration, and invasion. Moreover, B4GALNT3 increased the LacdiNAc modification of β₁ integrin, leading to decreased phosphorylation of focal adhesion kinase (FAK), Src, paxillin, Akt, and ERK1/2. B4GALNT3-mediated suppression of cell migration and invasion were substantially reversed by concomitant expression of constitutively active Akt or MEK. We conclude that B4GALNT3 predicts a favorable prognosis for NB and suppresses the malignant phenotype via decreasing β₁ integrin signaling.
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