Evidence map›Paper›PMID 21741606›Full record

Trial reportThe American journal of cardiology2011

Comparison of aerobic versus resistance exercise training effects on metabolic syndrome (from the Studies of a Targeted Risk Reduction Intervention Through Defined Exercise - STRRIDE-AT/RT).

Lori A Bateman, Cris A Slentz, Leslie H Willis, A Tamlyn Shields, Lucy W Piner, Connie W Bales, Joseph A Houmard, William E Kraus

Registry-linked trialOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03355469 (Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome), which is not on this map. Cited by 105 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 10 pooled it
45.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03355469 phase2 / phase3completedstarted 2017, after this paper: background citation

Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome

Ran2017Enrolled91Registered outcomes6Posted comparisons36ConditionsMetabolic SyndromeArmsHigh intensity exercise, Low intensity exercise, Metformin, Placebo
PMID 26583801PMID 11300445PMID 22040838PMID 16115299PMID 23505172PMID 24299160PMID 24744384PMID 24947027PMID 25529367PMID 19567533PMID 12379578PMID 12677025other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 10 syntheses or guidelines pooled it, 227 citations in OpenAlex.

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  17. Psychosocial Correlates of Meeting National Guidelines for Muscle-Strengthening Activities in Latinas.Health education & behavior : the official publication of the Society for Public Health Education · 2022
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lori A BatemanDivision of Cardiovascular Medicine, Duke University Medical Center, Durham, North Carolina, USA. lori.bateman@duke.edu
Cris A Slentz
Leslie H Willis
A Tamlyn Shields
Lucy W Piner
Connie W Bales
Joseph A Houmard
William E Kraus
Duke Medical Center · USEast Carolina University · USDuke University Hospital · US

Funding

Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6M
PERIPHERAL EFFECTS OF EXERCISE ON CARDIOVASCULAR HEALTHR01HL057354 · NHLBI · DUKE UNIVERSITY · PI KRAUS, WILLIAM E · 1998 to 2008
$5.5M
NHLBI NIH HHS HL-57354NHLBI NIH HHS R01 HL057354NIA NIH HHS P30 AG028716
6 · The paper itself

Abstract

Aerobic training (AT) improves the metabolic syndrome (MS) and its component risk factors; however, to our knowledge, no randomized clinical studies have addressed whether resistance training (RT) improves the MS when performed alone or combined with AT. Sedentary, overweight dyslipidemic men and women, aged 18 to 70 years completed a 4-month inactive run-in period and were randomized to 1 of 3 eight-month exercise programs (n = 196). The exercise programs were (1) RT (3 days/week, 3 sets/day of 8 to 12 repetitions of 8 different exercises targeting all major muscle groups); (2) AT (∼120 minutes/week at 75% of the maximum oxygen uptake), and (3) AT and RT combined (AT/RT) (exact combination of AT and RT). Of the 196 randomized patients, 144 completed 1 of the 3 exercise programs. The 86 participants with complete data for all 5 MS criteria were used in the present analysis, and a continuous MS z score was calculated. Eight months of RT did not change the MS score. AT improved the MS score (p <0.07) and showed a trend toward significance compared to RT (p <0.10). AT/RT significantly decreased the MS score and was significantly different from RT alone. In conclusion, RT was not effective at improving the MS score; however, AT was effective. Combined AT and RT was similarly effective but not different from AT alone. When weighing the time commitment versus health benefit, the data suggest that AT alone was the most efficient mode of exercise for improving cardiometabolic health.

Indexed as

AdolescentAdultAgedBody Mass IndexExercise TherapyFemaleHumansMaleMetabolic SyndromeMiddle AgedNorth CarolinaOxygen ConsumptionPatient ComplianceResistance TrainingRisk FactorsRisk Reduction Behavior

Identifiers

PMID21741606
PMCPMC3752599
OpenAlexW2079020384

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.