ArticleNeurotoxicology and teratology
Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish.
Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Review
- Zebrafish: A Pharmacological Model for Learning and Memory Research.Molecules (Basel, Switzerland) · 2022Review
- Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish.International journal of molecular sciences · 2022Review
- Modelling ADHD-Like Phenotypes in Zebrafish.Current topics in behavioral neurosciences · 2022Review
- Paternal exposure to a common pharmaceutical (Ritalin) has transgenerational effects on the behaviour of Trinidadian guppies.Scientific reports · 2021Article
- Effects of sub-chronic methylphenidate on risk-taking and sociability in zebrafish (Danio rerio).Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Effects of methylphenidate on the aggressive behavior, serotonin and dopamine levels, and dopamine-related gene transcription in brain of male Nile tilapia (Oreochromis niloticus).Fish physiology and biochemistry · 2019Article
- Stability and uptake of methylphenidate and ritalinic acid in nine-spine stickleback (Pungitius pungitius) and water louse (Asellus aquaticus).Environmental science and pollution research international · 2019Article
- Dopamine DBehavioural brain research · 2019Article
- Utilizing zebrafish and okadaic acid to study Alzheimer's disease.Neural regeneration research · 2018Review
- Delayed effects of developmental exposure to low levels of the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB126) on adult zebrafish behavior.Neurotoxicology · 2016Article
- Pharmacological analyses of learning and memory in zebrafish (Danio rerio).Pharmacology, biochemistry, and behavior · 2015Review
- Developmental Deltamethrin Exposure Causes Persistent Changes in Dopaminergic Gene Expression, Neurochemistry, and Locomotor Activity in Zebrafish.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Chlorpyrifos and malathion have opposite effects on behaviors and brain size that are not correlated to changes in AChE activity.Neurotoxicology · 2015Article
- Molecular psychiatry of zebrafish.Molecular psychiatry · 2015Article
- Chronic dietary exposure to pyrolytic and petrogenic mixtures of PAHs causes physiological disruption in zebrafish--part II: behavior.Environmental science and pollution research international · 2014Article
- Zebrafish model systems for developmental neurobehavioral toxicology.Birth defects research. Part C, Embryo today : reviews · 2013Review
- A robotics-based behavioral paradigm to measure anxiety-related responses in zebrafish.PloS one · 2013Article
- The developing utility of zebrafish models for cognitive enhancers research.Current neuropharmacology · 2012Article
- Distinct effects of ketamine and acetyl L-carnitine on the dopamine system in zebrafish.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
As more adults take the stimulant medication methylphenidate to treat attention deficit hyperactivity disorder (ADHD) residual type, the risk arises with regard to exposure during early development if people taking the medication become pregnant. We studied the neurobehavioral effects of methylphenidate in zebrafish. Zebrafish offer cellular reporter systems, continuous visual access and molecular interventions such as morpholinos to help determine critical mechanisms underlying neurobehavioral teratogenicity. Previously, we had seen that persisting neurobehavioral impairment in zebrafish with developmental chlorpyrifos exposure was associated with disturbed dopamine systems. Because methylphenidate is an indirect dopamine agonist, it was thought that it might also cause persistent behavioral impairment after developmental exposure. Zebrafish embryos were exposed to the ADHD stimulant medication methylphenidate 0-5 days post fertilization (12.5-50mg/l). They were tested for long-term behavioral effects as adults. Methylphenidate exposure (50mg/l) caused significant increases in dopamine, norepinepherine and serotonin on day 6 but not day 30 after fertilization. In the novel tank diving test of predatory avoidance developmental methylphenidate (50mg/l) caused a significant reduction in the normal diving response. In the three-chamber spatial learning task early developmental methylphenidate (50mg/l) caused a significant impairment in choice accuracy. These data show that early developmental exposure of zebrafish to methylphenidate causes a long-term impairment in neurobehavioral plasticity. The identification of these functional deficits in zebrafish enables further studies with this model to determine how molecular and cellular mechanisms are disturbed to arrive at this compromised state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.