ArticleNeuroscience and biobehavioral reviews2012
BTBR T+tf/J mice: autism-relevant behaviors and reduced fractone-associated heparan sulfate.
Article in Neuroscience and biobehavioral reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Auditory processing deficits in autism spectrum disorder: mechanisms, animal models, and therapeutic directions.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Amygdalar neurotransmission alterations in the BTBR mice model of idiopathic autism.Translational psychiatry · 2024Article
- Behavioral regulation by perineuronal nets in the prefrontal cortex of the CNTNAP2 mouse model of autism spectrum disorder.Frontiers in behavioral neuroscience · 2023Article
- Atypical perineuronal nets in the CA2 region interfere with social memory in a mouse model of social dysfunction.Molecular psychiatry · 2022Article
- Altered expression of glycan patterns and glycan-related genes in the medial prefrontal cortex of the valproic acid rat model of autism.Frontiers in cellular neuroscience · 2022Article
- Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders.Nature communications · 2021Article
- Somatosensorimotor and Odor Modification, Along with Serotonergic Processes Underlying the Social Deficits in BTBR T+ Itpr3Neuroscience · 2020Article
- Cerebellar Morphology and Behavioral Profiles in Mice Lacking Heparan SulfateJournal of developmental biology · 2020Article
- Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder.Molecular neurobiology · 2020Article
- From Multisensory Assessment to Functional Interpretation of Social Behavioral Phenotype in Transgenic Mouse Models for Autism Spectrum Disorders.Frontiers in psychiatry · 2020Review
- Characterization of behavioral phenotypes in the BTBR TExperimental animals · 2019Article
- Juvenile Shank3b deficient mice present with behavioral phenotype relevant to autism spectrum disorder.Behavioural brain research · 2019Article
- Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers.Cortex; a journal devoted to the study of the nervous system and behavior · 2017Article
- Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders.Biomolecules & therapeutics · 2016Review
- Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism.Psychopharmacology · 2016Article
- Neuronal correlates of asocial behavior in a BTBR T (+) Itpr3(tf)/J mouse model of autism.Frontiers in behavioral neuroscience · 2015Article
- Article
- Effect of social odor context on the emission of isolation-induced ultrasonic vocalizations in the BTBR T+tf/J mouse model for autism.Frontiers in neuroscience · 2015Article
- The role of behavior in translational models for psychopathology: functionality and dysfunctional behaviors.Neuroscience and biobehavioral reviews · 2013Review
- Sugar glues for broken neurons.Biomolecular concepts · 2013Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
BTBR T+tf/J (BTBR) mice have emerged as strong candidates to serve as models of a range of autism-relevant behaviors, showing deficiencies in social behaviors; reduced or unusual ultrasonic vocalizations in conspecific situations; and enhanced, repetitive self-grooming. Recent studies have described their behaviors in a seminatural visible burrow system (VBS); a Social Proximity Test in which avoidance of a conspecific is impossible; and in an object approach and investigation test evaluating attention to specific objects and potential stereotypies in the order of approaching/investigating objects. VBS results confirmed strong BTBR avoidance of conspecifics and in the Social Proximity Test, BTBR showed dramatic differences in several close-in behaviors, including specific avoidance of a nose-to-nose contact that may potentially be related to gaze-avoidance. Diazepam normalized social avoidance by BTBRs in a Three-Chamber Test, and some additional behaviors - but not nose to nose avoidance - in the Social Proximity Test. BTBR also showed higher levels of preference for particular objects, and higher levels of sequences investigating 3- or 4-objects in the same order. Heparan sulfate (HS) associated with fractal structures in the subventricular zone of the lateral ventricles was severely reduced in BTBR. HS may modulate the functions of a range of growth and guidance factors during development, and HS abnormalities are associated with relevant brain (callosal agenesis) and behavioral (reductions in sociality) changes; suggesting the value of examination of the dynamics of the HS system in the context of autism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.