Evidence map›Paper›PMID 21740882›Full record

ReviewHeart rhythm2011

Autoantibodies and cardiac arrhythmias.

Hon-Chi Lee, Kristin T L Huang, Xiao-Li Wang, Win-Kuang Shen

Abstract readReview
In one paragraph

Review in Heart rhythm, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Arrhythmias in Autoimmune Diseases: Immune-Mediated Mechanisms and Management.Journal of cardiovascular development and disease · 2026
    Review
  2. Article
  3. Metabolic and Inflammatory Mechanisms Driving Atrial Fibrillation.Annual review of pharmacology and toxicology · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. COVID-19 HEART unveiling as atrial fibrillation: pathophysiology, management and future directions for research.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
    Review
  10. Autoantibodies in Atrial Fibrillation-State of the Art.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Sinus Tachycardia: a Multidisciplinary Expert Focused Review.Circulation. Arrhythmia and electrophysiology · 2022
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. The Role of Autoantibodies in Arrhythmogenesis.Current cardiology reports · 2020
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Hon-Chi LeeDepartment of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA. Lee.honchi@mayo.edu
Kristin T L Huang
Xiao-Li Wang
Win-Kuang Shen

Funding

Type 2 Diabetes and Vascular BK Channel RegulationR01HL074180 · NHLBI · MAYO CLINIC ROCHESTER · PI LEE, HON-CHI · 2003 to 2018
$4.8M
Endothelial BK Channel Regulation by Caveolae TargetingR01HL080118 · NHLBI · MAYO CLINIC ROCHESTER · PI LEE, HON-CHI · 2006 to 2010
$1.8M
Regulation of Vascular BK Channels in DiabetesR56HL074180 · NHLBI · MAYO CLINIC ROCHESTER · PI LEE, HON-CHI · 2008 to 2008
$378k
NHLBI NIH HHS HL080118NHLBI NIH HHS HL74180NHLBI NIH HHS R01 HL074180NHLBI NIH HHS R01 HL080118NHLBI NIH HHS R56 HL074180
6 · The paper itself

Abstract

Autoimmune diseases are associated with significant morbidity and mortality, afflicting about 5% of the US population. They encompass a wide range of disorders that affect all organs of the human body and have a predilection for women. In the past, autoimmune pathogenesis was not thought to be a major mechanism for cardiovascular disorders, and potential relationships remain understudied. However, accumulating evidence suggests that a number of vascular and cardiac conditions are autoimmune mediated. Recent studies indicate that autoantibodies play an important role in the development of cardiac arrhythmias, including atrial fibrillation, modulation of autonomic influences on heart rate and rhythm, conduction system abnormalities, and ventricular arrhythmias. This article will review the current evidence for the role of autoantibodies in the development of cardiac arrhythmias.

Indexed as

AutoimmunityArrhythmias, CardiacAutoantibodiesHeart Conduction SystemHumansMorbiditySurvival RateUnited StatesAutoantibodies

Identifiers

PMID21740882
PMCPMC3855646

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.