ArticleBMC evolutionary biology2011
Evidence for acquisition of virulence effectors in pathogenic chytrids.
Article in BMC evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Unique trajectory of gene family evolution from genomic analysis of nearly all known species in an ancient yeast lineage.Molecular systems biology · 2025Article
- Comparative Genomics Reveals Intra and Inter Species Variation in the Pathogenic Fungus Batrachochytrium dendrobatidis.Genome biology and evolution · 2025Article
- Host-multiparasite interactions in amphibians: a review.Parasites & vectors · 2021Review
- Comparative Analysis of Rhizosphere Microbiomes of Southern Highbush Blueberry (Frontiers in microbiology · 2020Article
- PpCRN7 and PpCRN20 of Phythophthora parasitica regulate plant cell death leading to enhancement of host susceptibility.BMC plant biology · 2019Article
- Molecular Dating of the Emergence of Anaerobic Rumen Fungi and the Impact of Laterally Acquired Genes.mSystems · 2019Article
- Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.BMC biology · 2018Article
- RiCRN1, a Crinkler Effector From the Arbuscular Mycorrhizal FungusFrontiers in microbiology · 2018Article
- Genomic innovations linked to infection strategies across emerging pathogenic chytrid fungi.Nature communications · 2017Article
- A Perspective on CRN Proteins in the Genomics Age: Evolution, Classification, Delivery and Function Revisited.Frontiers in plant science · 2017Review
- Glycoside hydrolases family 20 (GH20) represent putative virulence factors that are shared by animal pathogenic oomycetes, but are absent in phytopathogens.BMC microbiology · 2016Article
- Contribution of Multiple Inter-Kingdom Horizontal Gene Transfers to Evolution and Adaptation of Amphibian-Killing Chytrid, Batrachochytrium dendrobatidis.Frontiers in microbiology · 2016Article
- Horizontal functional gene transfer from bacteria to fishes.Scientific reports · 2015Article
- Dimensions of Horizontal Gene Transfer in Eukaryotic Microbial Pathogens.PLoS pathogens · 2015Article
- Quantitative Proteomics of an Amphibian Pathogen, Batrachochytrium dendrobatidis, following Exposure to Thyroid Hormone.PloS one · 2015Article
- Transcriptome analysis of the entomopathogenic oomycete Lagenidium giganteum reveals putative virulence factors.Applied and environmental microbiology · 2014Article
- Oligopeptides as biomarkers of cyanobacterial subpopulations. Toward an understanding of their biological role.Toxins · 2014Review
- Secretome analysis reveals effector candidates associated with broad host range necrotrophy in the fungal plant pathogen Sclerotinia sclerotiorum.BMC genomics · 2014Article
- Single nucleus genome sequencing reveals high similarity among nuclei of an endomycorrhizal fungus.PLoS genetics · 2014Article
- The scale and evolutionary significance of horizontal gene transfer in the choanoflagellate Monosiga brevicollis.BMC genomics · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe decline in amphibian populations across the world is frequently linked to the infection of the chytrid fungus Batrachochytrium dendrobatidis (Bd). This is particularly perplexing because Bd was only recently discovered in 1999 and no chytrid fungus had previously been identified as a vertebrate pathogen.
resultsIn this study, we show that two large families of known virulence effector genes, crinkler (CRN) proteins and serine peptidases, were acquired by Bd from oomycete pathogens and bacteria, respectively. These two families have been duplicated after their acquisition by Bd. Additional selection analyses indicate that both families evolved under strong positive selection, suggesting that they are involved in the adaptation of Bd to its hosts.
conclusionsWe propose that the acquisition of virulence effectors, in combination with habitat disruption and climate change, may have driven the Bd epidemics and the decline in amphibian populations. This finding provides a starting point for biochemical investigations of chytridiomycosis.
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