ArticleJournal of proteome research2011
Discovery and characterization of the Crustacean hyperglycemic hormone precursor related peptides (CPRP) and orcokinin neuropeptides in the sinus glands of the blue crab Callinectes sapidus using multiple tandem mass spectrometry techniques.
Article in Journal of proteome research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Recent advances in mass spectrometry analysis of neuropeptides.Mass spectrometry reviews · 2023Review
- HyPep: An Open-Source Software for Identification and Discovery of Neuropeptides Using Sequence Homology Search.Journal of proteome research · 2023Article
- Mass Spectrometric Profiling of Neuropeptides inACS chemical neuroscience · 2020Article
- Quinetides: diverse posttranslational modified peptides of ribonuclease-like storage protein fromJournal of ginseng research · 2020Article
- Defining the Neuropeptidome of the Spiny Lobster Panulirus interruptus Brain Using a Multidimensional Mass Spectrometry-Based Platform.Journal of proteome research · 2015Article
- Quantitative neuropeptidomics study of the effects of temperature change in the crab Cancer borealis.Journal of proteome research · 2014Article
- Recent advances in coupling capillary electrophoresis-based separation techniques to ESI and MALDI-MS.Electrophoresis · 2014Review
- Gas-phase ion isomer analysis reveals the mechanism of peptide sequence scrambling.Analytical chemistry · 2014Article
- A multi-scale strategy for discovery of novel endogenous neuropeptides in the crustacean nervous system.Journal of proteomics · 2013Article
- Mass spectrometric characterization of the neuropeptidome of the ghost crab Ocypode ceratophthalma (Brachyura, Ocypodidae).General and comparative endocrinology · 2013Article
- Large-scale identification of endogenous secretory peptides using electron transfer dissociation mass spectrometry.Molecular & cellular proteomics : MCP · 2013Article
- High-definition de novo sequencing of crustacean hyperglycemic hormone (CHH)-family neuropeptides.Molecular & cellular proteomics : MCP · 2012Article
- Pressure-assisted capillary electrophoresis coupling with matrix-assisted laser desorption/ionization-mass spectrometric imaging for quantitative analysis of complex peptide mixtures.Analytical chemistry · 2012Article
- Mass Spectrometry-based Proteomics and Peptidomics for Systems Biology and Biomarker Discovery.Frontiers in biology · 2012Article
- Neuropeptide analysis with liquid chromatography-capillary electrophoresis-mass spectrometric imaging.Journal of separation science · 2012Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The crustacean sinus gland (SG) is a well-defined neuroendocrine site that produces numerous hemolymph-borne agents including the most complex class of endocrine signaling molecules-neuropeptides. Via a multifaceted mass spectrometry (MS) approach, 70 neuropeptides were identified including orcokinins, orcomyotropin, crustacean hyperglycemic hormone (CHH) precursor-related peptides (CPRPs), red pigment concentrating hormone (RPCH), pigment dispersing hormone (PDH), proctolin, RFamides, RYamides, and HL/IGSL/IYRamide. Among them, 15 novel orcokinins, 9 novel CPRPs, 1 novel orcomyotropin, 1 novel Ork/Orcomyotropin-related peptide, and 1 novel PDH were de novo sequenced via collision induced dissociation (CID) from the SG of a model organism Callinectes sapidus. Electron transfer dissociation (ETD) was used for sequencing of intact CPRPs due to their large size and higher charge state. Capillary isoelectric focusing (CIEF) was employed for separation of members of the orcokinin family, which is one of the most abundant neuropeptide families observed in the SG. Collectively, our study represents the most complete characterization of neuropeptides in the SG and provides a foundation for future investigation of the physiological function of neuropeptides in the SG of C. sapidus.
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