ArticleMolecular imaging and biology2012
Spectral unmixing imaging of wavelength-responsive fluorescent probes: an application for the real-time report of amyloid Beta species in Alzheimer's disease.
Article in Molecular imaging and biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
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- Two-Photon Fluorescent Probes for Amyloid-β Plaques Imaging In Vivo.Molecules (Basel, Switzerland) · 2023Review
- Evidence for Effects of Extracellular Vesicles on Physical, Inflammatory, Transcriptome and Reward Behaviour Status in Mice.International journal of molecular sciences · 2022Article
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- Preclinical Applications of Multi-Platform Imaging in Animal Models of Cancer.Cancer research · 2021Review
- Non-invasive synchronous monitoring of neutrophil migration using whole body near-infrared fluorescence-based imaging.Scientific reports · 2021Article
- Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo.Nature communications · 2020Article
- QuantitativeNeurophotonics · 2019Article
- Spectral Unmixing Imaging for Differentiating Brown Adipose Tissue Mass and Its Activation.Contrast media & molecular imaging · 2018Article
- Tuning the stereo-hindrance of a curcumin scaffold for the selective imaging of the soluble forms of amyloid beta species.Chemical science · 2017Article
- Imaging hydrogen peroxide in Alzheimer's disease via cascade signal amplification.Scientific reports · 2016Article
- Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning.Scientific reports · 2015Article
- Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease.Acta pharmaceutica Sinica. B · 2015Review
- A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease.Chemical communications (Cambridge, England) · 2014Article
- Use of a benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the Alzheimer's disease brain.Molecular imaging and biology · 2014Article
- Dual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding Proteins.Current organic chemistry · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe goal of the study was to investigate a method for the real-time assessment of a target concentration in vivo using a combination of a spectral unmixing technique and a fluorescent probe specific for amyloid beta (Aβ) species, the biomarkers for Alzheimer's disease (AD). PROCEDURES: The probe CRANAD-3 has a significant emission wavelength shift upon binding to Aβ species. It was used to differentiate a bound probe from an unbound probe in a phantom, ex vivo in brain slices and whole brain, and in vivo in a transgenic mouse model of AD.
resultsThe ex vivo unmixing imaging of AD brain clearly showed differential distribution of the bound and unbound probes between the brain tissue and blood vessels. The in vivo unmixed signals of bound CRANAD-3 reached a plateau with increasing dosage, demonstrating that these signals correspond to Aβ content, not probe injected dose.
conclusionThis study provided evidence that signals processed by the spectral unmixing technique could be used as a real-time reporter of Aβ species loading in vivo and ex vivo.
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