ArticleNeuroradiology2012
CT and MR perfusion can discriminate severe cerebral hypoperfusion from perfusion absence: evaluation of different commercial software packages by using digital phantoms.
Article in Neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Shine and darkle the blood vessels: Multiparameter hypersensitive MR angiography for diagnosis of panvascular diseases.Science advances · 2024Article
- Measuring brain perfusion by CT or MR as ancillary tests for diagnosis of brain death: a systematic review and meta-analysis.BJR open · 2024Article
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- A dynamic simulation framework for CT perfusion in stroke assessment built from first principles.Medical physics · 2021Article
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- Computed Tomography Perfusion is a Useful Adjunct to Computed Tomography Angiography in the Diagnosis of Brain Death.Clinical neuroradiology · 2019Article
- The Role of Neuroimaging in the Determination of Brain Death.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2018Article
- Accuracy of Computed Tomographic Perfusion in Diagnosis of Brain Death: A Prospective Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Renaissance of criticism on the concept of brain death--the role of legal medicine in the context of the interdisciplinary discussion.International journal of legal medicine · 2016Article
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- Biased visualization of hypoperfused tissue by computed tomography due to short imaging duration: improved classification by image down-sampling and vascular models.European radiology · 2015Article
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- Dynamic evaluation of stasis filling phenomenon with computed tomography in diagnosis of brain death.Neuroradiology · 2013Article
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Authors and funding
7 authors.
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Abstract
introductionComputed tomography perfusion (CTP) and magnetic resonance perfusion (MRP) are expected to be usable for ancillary tests of brain death by detection of complete absence of cerebral perfusion; however, the detection limit of hypoperfusion has not been determined. Hence, we examined whether commercial software can visualize very low cerebral blood flow (CBF) and cerebral blood volume (CBV) by creating and using digital phantoms.
methodsDigital phantoms simulating 0-4% of normal CBF (60 mL/100 g/min) and CBV (4 mL/100 g/min) were analyzed by ten software packages of CT and MRI manufacturers. Region-of-interest measurements were performed to determine whether there was a significant difference between areas of 0% and areas of 1-4% of normal flow.
resultsThe CTP software detected hypoperfusion down to 2-3% in CBF and 2% in CBV, while the MRP software detected that of 1-3% in CBF and 1-4% in CBV, although the lower limits varied among software packages.
conclusionCTP and MRP can detect the difference between profound hypoperfusion of <5% from that of 0% in digital phantoms, suggesting their potential efficacy for assessing brain death.
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