SynthesisOdontology2012
Periodontal disease as a risk factor for adverse pregnancy outcomes: a systematic review and meta-analysis of case-control studies.
Synthesis in Odontology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 7 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- The Risk of Preterm Birth in Women With Periodontitis: A Systematic Review and Meta-Analysis.International journal of dental hygiene · 2026Pooled it
- The association between periodontal disease and adverse pregnancy outcomes: a bibliometric analysis from 2000 to 2023.Frontiers in medicine · 2025Pooled it
- Oral Health, Anxiety, Depression, and Stress in Pregnancy: A Rapid Review of Associations and Implications for Perinatal Care.International journal of environmental research and public health · 2024Pooled it
- Effect of Treating Periodontal Disease in Pregnant Women to Reduce the Risk of Preterm Birth and Low Birth Weight: An Umbrella Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Periodontitis and Preeclampsia in Pregnancy: A Systematic Review and Meta-Analysis.Maternal and child health journal · 2022Pooled it
- Periodontal Disease and Adverse Neonatal Outcomes: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies.PloS one · 2013Pooled it
- Use of mouth rinse during pregnancy to improve birth and neonatal outcomes: a randomized controlled trial.BMC pregnancy and childbirth · 2015Trial
- Risk factors for preterm birth in an international prospective cohort of nulliparous women.PloS one · 2012Trial
- Predicting Miscarriage Risk Based on Periodontal and Hematological Parameters Using Artificial Neural Network and XGBoost Models.Diagnostics (Basel, Switzerland) · 2026Article
- From mother to child: a survey-based cross-sectional study of oral health practices and knowledge among Saudi women during their pregnancy.Frontiers in medicine · 2026Article
- Does Zn-Mediated Regulation of the Kynurenine Pathway Provide the Link Between Periodontal Disease and Diabetes?Biological trace element research · 2026Article
- Mathematical Modeling of Obstetric Variables: Influence of COVID-19, Periodontal Disease and Dental Care During Pregnancy.Biomedicines · 2025Article
- Are Inflammatory Markers and Periodontitis Effective in Predicting Miscarriage?Healthcare (Basel, Switzerland) · 2025Article
- Clinical and dental predictors of preterm birth using machine learning methods: the MOHEPI study.Scientific reports · 2024Article
- Trends in maternal oral health services at primary healthcare centers in Saudi Arabia: a cross-sectional study.BMC oral health · 2023Article
- Knowledge and Practice Behaviours of Obstetricians/Gynecologists and Midwives Concerning Periodontal Health and Pregnancy.Oral health & preventive dentistry · 2023Article
- The association between periodontal disease and risk of adverse maternal or neonatal outcomes: A systematic review and meta-analysis of analytical observational studies.Health science reports · 2023Article
- Adverse Pregnancy Outcomes and Maternal Periodontal Disease: An Overview on Meta-Analytic and Methodological Quality.Journal of clinical medicine · 2023Review
- Association between the Risk of Preterm Birth and Low Birth Weight with Periodontal Disease in Pregnant Women: An Umbrella Review.Dentistry journal · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal disease is a highly prevalent group of illnesses of microbial etiology, whose consequence is a severe breakdown of tooth-supporting structures. A link between periodontal infection and several systemic conditions, among which adverse pregnancy outcomes, has been suggested in the recent years. The aim of this review based on case-control studies was to evaluate if periodontal disease could be considered as a risk factor for preterm birth, low birth-weight and preterm low birth-weight. An electronic search (via Pubmed) was performed for case-control studies investigating the relationship between periodontal disease and adverse pregnancy outcomes. From the initially retrieved 417 articles, 17 case-control studies, accounting for a total of 10,148 patients, were included in the review and in the meta-analysis. The estimated odds ratio was 1.78 (CI 95%: 1.58, 2.01) for preterm birth, 1.82 (CI 95%: 1.51, 1.20) for low birth-weight and 3.00 (CI 95%: 1.93, 4.68) for preterm low birth-weight. Despite the results of the analysis of pooled data suggested a link between periodontal diseases and adverse pregnancy outcomes, the presence of important confounders, whose effect could not be addressed, prevents a validation of the meta-analysis outcomes. Further more accurate investigations based on individual data analysis could give a better insight into the topic of the present review.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.