ArticleWorld journal of urology2011
The influence of age on bioavailable and free testosterone is independent of body mass index and glucose levels.
Article in World journal of urology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Follicle stimulating hormone, its novel association with sex hormone binding globulin in men and postmenopausal women.Endocrine · 2017Article
- Serum variations of anti-mullerian hormone and total testosterone with aging in healthy adult Iranian men: A population-based study.PloS one · 2017Article
- Diagnosis and treatment of infertility-related male hormonal dysfunction.Nature reviews. Urology · 2016Review
- The association of obesity with sex hormone-binding globulin is stronger than the association with ageing--implications for the interpretation of total testosterone measurements.Clinical endocrinology · 2015Article
- Dynamic alteration of serum testosterone with aging: a cross-sectional study from Shanghai, China.Reproductive biology and endocrinology : RB&E · 2015Observational
- A validated age-related normative model for male total testosterone shows increasing variance but no decline after age 40 years.PloS one · 2014Article
- The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer.Advances in urology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the influence of age on serum levels of total testosterone (TT), bioavailable testosterone (BT), free testosterone (FT), and sex-hormone binding globulin (SHBG), considering the presence of fasting blood glucose levels and body mass index (BMI) in a selected male population.
methodsA total of 428 men were analyzed. Anthropometry was taken from all, considering BMI as general obesity indicative variable. Fasting blood samples were drawn for determination of plasma glucose levels and serum levels of albumin, TT, and SHBG. The values of BT and FT were calculated from TT, SHBG, and albumin, by Vermeulen's equation. Statistical significance was set at P ≤ 0.05.
resultsAge was negatively correlated to BT (r = -0.301; P < 0.001) and FT (r = -0.273; P < 0.001), but not to TT levels (r = 0.002, P = 0.974). Age was positively correlated to SHBG (r = 0.376; P < 0.001). Age was independently associated with the occurrence of high SHBG levels (OR = 1.07, 95%CI = 1.05-1.10, P < 0.001) and of low BT (OR = 1.04, 95%CI = 1.02-1.07, P < 0.001) and FT levels (OR = 1.05, 95%CI = 1.03-1.08, P < 0.001), but not with low levels of TT (P = 0.08).
conclusionsAge was significantly associated to high levels of SHBG and to low levels of BT and FT, without significant association to TT. This pattern was independent of BMI and glucose levels.
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