ArticleJournal of bone and mineral metabolism2012
Matrix extracellular phosphoglycoprotein is expressed in causative tumors of oncogenic osteomalacia.
Article in Journal of bone and mineral metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- The Intricacies of Renal Phosphate Reabsorption-An Overview.International journal of molecular sciences · 2024Review
- The Nose that Broke the Hip! Tumor Induced Osteomalacia Secondary to Phosphaturic Mesenchymal Nasal Tumor : A Case Report.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Altered immunolocalization of FGF23 in murine femora metastasized with human breast carcinoma MDA-MB-231 cells.Journal of bone and mineral metabolism · 2021Article
- A Normal FGF23 Does Not Preclude Tumor-Induced Osteomalacia.JBMR plus · 2021Article
- Consensus Recommendations for the Diagnosis and Management of X-Linked Hypophosphatemia in Belgium.Frontiers in endocrinology · 2021Review
- Severe, reversible dysphagia and malnutrition in a patient with tumour-induced hypophosphataemia.BMJ case reports · 2018Article
- CT and MR imaging features in phosphaturic mesenchymal tumor-mixed connective tissue: A case report.Oncology letters · 2018Article
- Integrated ovarian mRNA and miRNA transcriptome profiling characterizes the genetic basis of prolificacy traits in sheep (Ovis aries).BMC genomics · 2018Article
- Regulatory roles of miRNA-758 and matrix extracellular phosphoglycoprotein in cervical cancer.Experimental and therapeutic medicine · 2017Article
- The Foot That Broke Both Hips: A Case Report and Literature Review of Tumor-Induced Osteomalacia.Case reports in rheumatology · 2017Article
- Ga-68 DOTATOC PET/CT-Guided Biopsy and Cryoablation with Autoradiography of Biopsy Specimen for Treatment of Tumor-Induced Osteomalacia.Cardiovascular and interventional radiology · 2016Article
- MEPE Localization in the Craniofacial Complex and Function in Tooth Dentin Formation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Immunohistochemical and molecular detection of the expression of FGF23 in phosphaturic mesenchymal tumors including the non-phosphaturic variant.Diagnostic pathology · 2016Article
- Quantitative ELISA-Like Immunohistochemistry of Fibroblast Growth Factor 23 in Diagnosis of Tumor-Induced Osteomalacia and Clinical Characteristics of the Disease.Disease markers · 2016Article
- Tumor-Induced Osteomalacia: an Up-to-Date Review.Current rheumatology reports · 2015Review
- Phosphaturic mesenchymal tumour mixed connective tissue variant: report of three cases with unusual histological findings.International journal of clinical and experimental pathology · 2015Article
- Tumor-associated FGF-23-induced hypophosphatemic rickets in children: a case report and review of the literature.Pediatric nephrology (Berlin, Germany) · 2015Review
- Oncogenic osteomalacia, raised FGF-23, and renal Fanconi syndrome.QJM : monthly journal of the Association of Physicians · 2014Article
- Tumor-Induced Osteomalacia: Increased Level of FGF-23 in a Patient with a Phosphaturic Mesenchymal Tumor at the Tibia Expressing Periostin.Case reports in endocrinology · 2014Article
- Can features of phosphate toxicity appear in normophosphatemia?Journal of bone and mineral metabolism · 2012Review
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16 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oncogenic osteomalacia (OOM), or tumor-induced osteomalacia, is a rare disease characterized by renal phosphate wasting and osteomalacia. It arises due to the secretion of fibroblast growth factor 23 (FGF-23) from causative tumors. Matrix extracellular phosphoglycoprotein (MEPE) is predominantly expressed in odontoblasts, osteoblasts, and osteocytes. Although the presence of MEPE mRNA has been reported in some OOM tumors, little is known about the prevalence of MEPE expression in OOM tumors. In this study, the expression of MEPE and FGF-23 in OOM tumors was investigated at the transcriptional and translational levels. Eleven causative OOM tumors were analyzed by quantitative real-time reverse transcription-polymerase chain reaction and immunohistochemistry for MEPE and FGF-23 expression. Hemangiopericytomas and giant cell tumors, pathological diagnoses that are common in cases of OOM, were obtained from non-osteomalacic patients and analyzed as controls. The gene expression level of FGF23 and MEPE in OOM tumors was 10(4)- and 10(5)-times higher, respectively, than in non-OOM tumors. Immunohistochemical staining revealed that FGF-23 protein was expressed in all OOM tumors, and MEPE was expressed in 10 out of 11 OOM tumors. Thus, MEPE expression was common in OOM tumors, similar to FGF-23. These results indicate that, in addition to the hypophosphatemic effects of FGF-23, MEPE or the MEPE-derived acidic serine aspartate-rich MEPE-associated motif peptide may contribute to decreased bone mineralization in OOM patients.
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