ArticleInternational journal of clinical and experimental pathology2011
rAAV-mediated delivery of brain-derived neurotrophic factor promotes neurite outgrowth and protects neurodegeneration in focal ischemic model.
Article in International journal of clinical and experimental pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Brain-derived neuerotrophic factor and related mechanisms that mediate and influence progesterone-induced neuroprotection.Frontiers in endocrinology · 2024Review
- Selected Factors of Vascular Changes: The Potential Pathological Processes Underlying Primary Headaches in Children.Children (Basel, Switzerland) · 2022Article
- Article
- Review
- Headache in Children: Selected Factors of Vascular Changes Involved in Underlying Processes of Idiopathic Headaches.Children (Basel, Switzerland) · 2020Review
- Preventive Triple Gene Therapy Reduces the Negative Consequences of Ischemia-Induced Brain Injury after Modelling Stroke in a Rat.International journal of molecular sciences · 2020Article
- TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells.Neurotoxicity research · 2020Article
- Novel approaches for the delivery of therapeutics in ischemic stroke.Drug discovery today · 2020Review
- Icariside II, a PDE5 Inhibitor, Suppresses Oxygen-Glucose Deprivation/Reperfusion-Induced Primary Hippocampal Neuronal Death Through Activating the PKG/CREB/BDNF/TrkB Signaling Pathway.Frontiers in pharmacology · 2020Article
- Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain.Frontiers in cellular neuroscience · 2019Review
- AAV-Syn-BDNF-EGFP Virus Construct Exerts Neuroprotective Action on the Hippocampal Neural Network during Hypoxia In Vitro.International journal of molecular sciences · 2018Article
- Neuroprotective and regenerative roles of intranasal Wnt-3a administration after focal ischemic stroke in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke.Progress in neurobiology · 2016Review
- Evaluation of Gene Therapy as an Intervention Strategy to Treat Brain Injury from Stroke.Frontiers in molecular neuroscience · 2016Review
- Mechanisms of cell-cell interaction in oligodendrogenesis and remyelination after stroke.Brain research · 2015Review
- BDNF-TrkB pathway mediates neuroprotection of hydrogen sulfide against formaldehyde-induced toxicity to PC12 cells.PloS one · 2015Article
- A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis.Neural regeneration research · 2014Article
- Drug delivery systems for the treatment of ischemic stroke.Pharmaceutical research · 2013Review
- Progesterone, brain-derived neurotrophic factor and neuroprotection.Neuroscience · 2013Review
- The neuroprotective roles of BDNF in hypoxic ischemic brain injury.Biomedical reports · 2013Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is one of the neurological diseases which lead to permanently neuronal damage after temporary or long-term occlusion of vessels or after heart attack. However, there are few efficient strategies to prevent or treat this kind of insult in clinical because the consequence is irreversible and could be long-lasting after the onset of stroke. Gene therapy especially using viral system has long been addressed to be of great potential to reduce the damage. Here, we generated recombinant adeno-associated virus (rAAV) carrying brain-derived neurotrophic factor (BDNF) gene. Cells infected with rAAV-BDNF could be able to produce functional BDNF which promoted neurite outgrowth and protected neurons from apoptosis induced by serum deprivation. Further more, single injection of rAAV showed neuroprotection against cell death in focal ischemic model. These results showed that rAAV-mediated gene delivery is functional, which shed light to the future application of viral system-based gene therapy in clinical.
Indexed as
Identifiers
21738820PMC3127070W165285763What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.