ArticlePloS one2011
Semaphorin-1a is required for Aedes aegypti embryonic nerve cord development.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Challenges of Robust RNAi-Mediated Gene Silencing inInternational journal of molecular sciences · 2024Article
- Article
- Article
- Characterization of plexinA and two distinct semaphorin1a transcripts in the developing and adult cricket Gryllus bimaculatus.The Journal of comparative neurology · 2020Article
- Characterization of a broad-based mosquito yeast interfering RNA larvicide with a conserved target site in mosquito semaphorin-1a genes.Parasites & vectors · 2019Article
- Preparation and Use of a Yeast shRNA Delivery System for Gene Silencing in Mosquito Larvae.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Review
- Redeployment of a conserved gene regulatory network during Aedes aegypti development.Developmental biology · 2016Article
- High-throughput cis-regulatory element discovery in the vector mosquito Aedes aegypti.BMC genomics · 2016Article
- Chitosan/interfering RNA nanoparticle mediated gene silencing in disease vector mosquito larvae.Journal of visualized experiments : JoVE · 2015Article
- Role of semaphorin-1a in the developing visual system of the disease vector mosquito Aedes aegypti.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Chitosan/siRNA nanoparticle targeting demonstrates a requirement for single-minded during larval and pupal olfactory system development of the vector mosquito Aedes aegypti.BMC developmental biology · 2014Article
- Examination of the genetic basis for sexual dimorphism in the Aedes aegypti (dengue vector mosquito) pupal brain.Biology of sex differences · 2014Article
- The molecular biology of the olive fly comes of age.BMC genetics · 2014Article
- Requirement for commissureless2 function during dipteran insect nerve cord development.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Stage-specific transcription during development of Aedes aegypti.BMC developmental biology · 2013Article
- Article
- Disruption of Aedes aegypti olfactory system development through chitosan/siRNA nanoparticle targeting of semaphorin-1a.PLoS neglected tropical diseases · 2013Article
- Slit/Robo-mediated axon guidance in Tribolium and Drosophila: divergent genetic programs build insect nervous systems.Developmental biology · 2012Article
- Developmental neurogenetics of sexual dimorphism inFrontiers in ecology and evolutionArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Although mosquito genome projects have uncovered orthologues of many known developmental regulatory genes, extremely little is known about mosquito development. In this study, the role of semaphorin-1a (sema1a) was investigated during vector mosquito embryonic ventral nerve cord development. Expression of sema1a and the plexin A (plexA) receptor are detected in the embryonic ventral nerve cords of Aedes aegypti (dengue vector) and Anopheles gambiae (malaria vector), suggesting that Sema1a signaling may regulate mosquito nervous system development. Analysis of sema1a function was investigated through siRNA-mediated knockdown in A. aegypti embryos. Knockdown of sema1a during A. aegypti development results in a number of nerve cord phenotypes, including thinning, breakage, and occasional fusion of the longitudinal connectives, thin or absent commissures, and general distortion of the nerve cord. Although analysis of Drosophila melanogaster sema1a loss-of-function mutants uncovered many similar phenotypes, aspects of the longitudinal phenotypes differed between D. melanogaster and A. aegypti. The results of this investigation suggest that Sema1a is required for development of the insect ventral nerve cord, but that the developmental roles of this guidance molecule have diverged in dipteran insects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.