ArticlePloS one2011
Enzymes are enriched in bacterial essential genes.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Exploring the enzymatic repertoires of Bacteria and Archaea and their associations with metabolic maps.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Recent advances in the characterization of essential genes and development of a database of essential genes.iMeta · 2024Review
- Assigning Functions of Unknown Enzymes by High-Throughput Enzyme Characterization.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Article
- Comparative analysis of the Burkholderia cenocepacia K56-2 essential genome reveals cell envelope functions that are uniquely required for survival in species of the genus Burkholderia.Microbial genomics · 2017Article
- Cas9 Nickase-Assisted RNA Repression Enables Stable and Efficient Manipulation of Essential Metabolic Genes inFrontiers in microbiology · 2017Article
- A Comprehensive Overview of Online Resources to Identify and Predict Bacterial Essential Genes.Frontiers in microbiology · 2017Review
- Evolutionary conservation analysis between the essential and nonessential genes in bacterial genomes.Scientific reports · 2015Article
- Comparative analysis of essential genes in prokaryotic genomic islands.Scientific reports · 2015Article
- Identification of essential genes of the periodontal pathogen Porphyromonas gingivalis.BMC genomics · 2012Article
- Exploration of the core metabolism of symbiotic bacteria.BMC genomics · 2012Article
- Comparative genomics analysis of Mycobacterium ulcerans for the identification of putative essential genes and therapeutic candidates.PloS one · 2012Article
- Evaluating the suitability of essential genes as targets for antibiotic screening assays using proteomics.Protein & cell · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essential genes, those indispensable for the survival of an organism, play a key role in the emerging field, synthetic biology. Characterization of functions encoded by essential genes not only has important practical implications, such as in identifying antibiotic drug targets, but can also enhance our understanding of basic biology, such as functions needed to support cellular life. Enzymes are critical for almost all cellular activities. However, essential genes have not been systematically examined from the aspect of enzymes and the chemical reactions that they catalyze. Here, by comprehensively analyzing essential genes in 14 bacterial genomes in which large-scale gene essentiality screens have been performed, we found that enzymes are enriched in essential genes. Essential enzymes have overrepresented ligases (especially those forming carbon-oxygen bonds and carbon-nitrogen bonds), nucleotidyltransferases and phosphotransferases, while have underrepresented oxidoreductases. Furthermore, essential enzymes tend to associate with more gene ontology domains. These results, from the aspect of chemical reactions, provide further insights into the understanding of functions needed to support natural cellular life, as well as synthetic cells, and provide additional parameters that can be integrated into gene essentiality prediction algorithms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.