ArticlePloS one2011
Mutation rate switch inside Eurasian mitochondrial haplogroups: impact of selection and consequences for dating settlement in Europe.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Variation in the Substitution Rates among the Human Mitochondrial Haplogroup U Sublineages.Genome biology and evolution · 2022Article
- Human molecular evolutionary rate, time dependency and transient polymorphism effects viewed through ancient and modern mitochondrial DNA genomes.Scientific reports · 2021Article
- Mitochondrial DNA in osteoarthritis disease.Clinical rheumatology · 2020Article
- Counterbalancing the time-dependent effect on the human mitochondrial DNA molecular clock.BMC evolutionary biology · 2020Article
- Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes.Nature reviews. Rheumatology · 2018Review
- Spatial and temporal simulation of human evolution. Methods, frameworks and applications.Current genomics · 2014Article
- Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions.Human molecular genetics · 2014Article
- Ancient DNA analysis of 8000 B.C. near eastern farmers supports an early neolithic pioneer maritime colonization of Mainland Europe through Cyprus and the Aegean Islands.PLoS genetics · 2014Article
- Article
- Review
- Computer programs and methodologies for the simulation of DNA sequence data with recombination.Frontiers in genetics · 2013Article
- MtDNA analysis of global populations support that major population expansions began before Neolithic Time.Scientific reports · 2012Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
R-lineage mitochondrial DNA represents over 90% of the European population and is significantly present all around the planet (North Africa, Asia, Oceania, and America). This lineage played a major role in migration "out of Africa" and colonization in Europe. In order to determine an accurate dating of the R lineage and its sublineages, we analyzed 1173 individuals and complete mtDNA sequences from Mitomap. This analysis revealed a new coalescence age for R at 54.500 years, as well as several limitations of standard dating methods, likely to lead to false interpretations. These findings highlight the association of a striking under-accumulation of synonymous mutations, an over-accumulation of non-synonymous mutations, and the phenotypic effect on haplogroup J. Consequently, haplogroup J is apparently not a Neolithic group but an older haplogroup (Paleolithic) that was subjected to an underestimated selective force. These findings also indicated an under-accumulation of synonymous and non-synonymous mutations localized on coding and non-coding (HVS1) sequences for haplogroup R0, which contains the major haplogroups H and V. These new dates are likely to impact the present colonization model for Europe and confirm the late glacial resettlement scenario.
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