ArticlePloS one2011
Diversity of murine norovirus strains isolated from asymptomatic mice of different genetic backgrounds within a single U.S. research institute.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- N-glycoproteomic analyses of human intestinal enteroids, varying in histo-blood group geno- and phenotypes, reveal a wide repertoire of fucosylated glycoproteins.Glycobiology · 2024Article
- Genetic diversity of murine norovirus populations less susceptible to chlorine.Frontiers in microbiology · 2024Article
- Mouse Norovirus Uses Host Metabolites to Enhance Receptor Binding and Evade Immune Recognition.Medical research archives · 2022Article
- Murine norovirus virulence factor 1 (VF1) protein contributes to viral fitness during persistent infection.The Journal of general virology · 2021Article
- Isolation and Identification of a Murine Norovirus Persistent Infection Strain in China.Frontiers in veterinary science · 2020Article
- Murine norovirus infection in Brazilian animal facilities.Experimental animals · 2017Article
- Viral Population Changes during Murine Norovirus Propagation in RAW 264.7 Cells.Frontiers in microbiology · 2017Article
- Histologic Lesions Induced by Murine Norovirus Infection in Laboratory Mice.Veterinary pathology · 2016Review
- Protective role of murine norovirus against Pseudomonas aeruginosa acute pneumonia.Veterinary research · 2015Article
- Article
- Infection with murine norovirus 4 does not alter Helicobacter-induced inflammatory bowel disease in Il10(-/-) mice.Comparative medicine · 2014Article
- Detection of murine norovirus by reverse transcription loop-mediated isothermal amplification.Journal of virological methods · 2014Article
- A broadly reactive one-step SYBR Green I real-time RT-PCR assay for rapid detection of murine norovirus.PloS one · 2014Article
- Influence of genome-scale RNA structure disruption on the replication of murine norovirus--similar replication kinetics in cell culture but attenuation of viral fitness in vivo.Nucleic acids research · 2013Article
- Natural infection of murine norovirus in conventional and specific pathogen-free laboratory mice.Frontiers in microbiology · 2013Article
- Plaque assay for murine norovirus.Journal of visualized experiments : JoVE · 2012Article
- Development of a reverse-genetics system for murine norovirus 3: long-term persistence occurs in the caecum and colon.The Journal of general virology · 2012Article
- Protruding domain of capsid protein is necessary and sufficient to determine murine norovirus replication and pathogenesis in vivo.Journal of virology · 2012Article
- Experimental inoculation of juvenile rhesus macaques with primate enteric caliciviruses.PloS one · 2012Article
- Comparative murine norovirus studies reveal a lack of correlation between intestinal virus titers and enteric pathology.Virology · 2011Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Antibody prevalence studies in laboratory mice indicate that murine norovirus (MNV) infections are common, but the natural history of these viruses has not been fully established. This study examined the extent of genetic diversity of murine noroviruses isolated from healthy laboratory mice housed in multiple animal facilities within a single, large research institute- the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIAID-NIH) in Bethesda, Maryland, U.S. Ten distinct murine norovirus strains were isolated from various tissues and feces of asymptomatic wild type sentinel mice as well as asymptomatic immunodeficient (RAG 2(-/-)) mice. The NIH MNV isolates showed little cytopathic effect in permissive RAW264.7 cells in early passages, but all isolates examined could be adapted to efficient growth in cell culture by serial passage. The viruses, although closely related in genome sequence, were distinguishable from each other according to facility location, likely due to the introduction of new viruses into each facility from separate sources or vendors at different times. Our study indicates that the murine noroviruses are widespread in these animal facilities, despite rigorous guidelines for animal care and maintenance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.